EPIDEMIOLOGY OF INSOMNIA & MENTAL ILLNESS IN ADOLESCENCE

描述（改编自申请人的摘要）：这是一个新的RO 1 申请进行一项为期五年的失眠症、精神病、 青春期的精神障碍和物质使用。该应用程序适合在两个 NIMH优先领域：1）主要研究者是新的研究者， 2)主题将本申请置于对PA 95 -014的响应之下， 睡眠与觉醒的基础与临床研究。 这项研究的主要目的是检查失眠的途径， 青少年时期的特定精神障碍和物质使用。更 具体而言，我们将：1）估计特定精神疾病的风险增加 青少年失眠导致的疾病和物质使用; 2） 评估失眠发生之前、同时或之后， 精神/行为问题和物质使用，以及慢性和偶发性 失眠，通过检查失眠的自然过程;和3）估计 流行病学调查中青少年失眠的患病率和发病率 定义人口。 我们提出了一项前瞻性研究的人口样本的1,000名青少年和 父母对，在基线时进行评估，24个月后再次进行评估 interval.青少年基线年龄为13 - 15岁。随机 参与者的子样本（N=156）将被指定用于纵向 每月评估睡眠障碍的子研究， 失眠的自然过程 拟议的前瞻性研究提供了一个独特的机会， 青少年失眠的性质和潜在后遗症的研究。与 这一流行病学基础，未来的检查HPA轴失调， 多导睡眠图确定的睡眠结构可以提供以下信息 失眠、精神疾病和抑郁症之间的潜在联系 疾病和物质使用。同样，在假设的支持下， 精神障碍和物质使用相关的预期风险增加 对于失眠症，拟议中的研究也可能为失眠症提供基础。 干预试验，治疗青少年失眠，以减少风险， 精神障碍和药物滥用

DESCRIPTION (Adapted from the Applicant's Abstract): This is a new RO1 application for a five-year study of the epidemiology of insomnia, mental disorders and substance use during adolescence. The application fits within two NIMH priority areas: 1) the principal investigator is a new investigator, and 2) the subject matter places this application under a response to PA95-014, Basic and Clinical Research on Sleep and Wakefulness. The primary purpose of the proposed study is to examine pathways from insomnia to specific mental disorders and substance use during adolescence. More specifically, we will: 1 ) estimate the increased risk of specific mental disorders and substance use attributable to insomnia among adolescents; 2) assess the occurrence of insomnia as prior, concurrent or subsequent to mental/behavioral problems and substance use, as well as chronic and episodic insomnia, by examining the natural course of insomnia; and 3) estimate the prevalence and incidence of insomnia among adolescents in an epidemiologically defined population. We propose a prospective study of a population sample of 1,000 adolescent and parent pairs, with an assessment at baseline and again after a 24-month interval. Adolescents will be 13 - 15 years old at baseline. A random sub-sample of participants (N=156) will be designated for a longitudinal sub-study with monthly assessments of sleep disturbances in order to examine the natural course of insomnia. The proposed prospective study provides a unique opportunity to extend prior research on the nature and potential sequelae of insomnia in adolescence. With this epidemiologic grounding, future examination of HPA axis dysregulation and polysomnographically determined sleep architecture could provide information on potential mechanisms of the hypothesized links between insomnia, mental disorders and substance use. Similarly, with support for the hypothesized prospective increased risk for mental disorders and substance use associated with insomnia, the proposed research may also provide grounding for an intervention trial, treating adolescent insomnia in order to reduce the risk of mental disorders and substance use.