AMYGDALA AND SLEEP

描述：（改编自研究者摘要） 与压力有关的睡眠障碍，特别是失眠，在美国和加拿大广泛流行。 一般人口。很少有好的动物模型来研究 失眠或睡眠异常的潜在机制 精神疾病内德·卡林博士一直在研究杏仁核的作用 在恒河猴的情绪处理中，人类的相关模型 情感和精神病理学与Kalin博士合作，校长 研究人员从患有杏仁核的恒河猴中获得了初步数据 这表明杏仁核介导了对睡眠的压力效应， 可能对快速眼动/非快速眼动睡眠周期也很重要。 在这份修订后的提案中，主要研究者计划研究恒河猴， 杏仁核全部双侧病变和杏仁核双侧病变的猴 杏仁核的中央核，杏仁核的主要输出部位。 利用遥测技术，她将比较正常情况下， 条件和应对各种压力。这些研究将 确定杏仁核在正常睡眠组织中的作用， 对情绪和身体压力的反应。从这些获得的结果 研究应该增加我们对睡眠机制的理解 精神障碍和失眠的异常。

DESCRIPTION: (Adapted from the Investigator's Abstract) Stress-related sleep disorders, notably insomnia, are widely prevalent in the general population. There are few good animal models in which to study the mechanisms underlying insomnia or the sleep abnormalities associated with psychiatric disorders. Dr. Ned Kalin has been studying the role of the amygdala in emotional processing in the rhesus monkey, a relevant model for human emotion and psychopathology. In collaboration with Dr. Kalin, the Principal Investigator has obtained preliminary data from rhesus monkeys with amygdala lesions which suggest that the amygdala mediates stress effects on sleep and may be important in organizing REM/NREM sleep cycles as well. In this revised proposal, the Principal Investigator plans to study rhesus monkeys with total, bilateral lesions of the amygdala, and bilateral lesions of the central nucleus of the amygdala, the major output site from the amygdala. Using telemetry, she will compare sleep patterns under normal, unrestrained conditions and in response to a variety of stressors. These studies will establish the role of the amygdala in normal sleep organization as well as in response to emotional and physical stressors. Results obtained from these studies should increase our understanding of the mechanisms underlying sleep abnormalities in psychiatric disorders and insomnia.