BOTANICAL CENTER FOR AGE-RELATED DISEASES

拟议中的普渡大学-阿拉巴马大学伯明翰分校(UAB)植物学中心是一个基础研究中心，组织和维护一个多学科的植物学实验研究计划作为膳食补充剂，并作为植物学认证、培训和消费者教育的国家资源。我们在植物科学、制药学和生药学、分析能力、生物统计学以及关于饮食成分的生物利用度和新陈代谢的人类和动物研究方面拥有强大的历史。该中心专注于普渡大学和阿拉巴马大学伯明翰分校的不同基础研究和教育实力，并在普渡大学和印第安纳大学医学院的临床支持下，重点研究植物中的活性成分，重点是多酚类化合物，并确定它们在降低与年龄相关的疾病(包括骨质疏松、癌症、心血管疾病和神经退化)风险方面的有效性。为了促进这项研究，植物学中心将提供包括以下支持核心的共享资源：行政和生物统计学；植物学和教育学；分析：临床、加速器质谱学和生物分析系统；以及活体评估。此外，植物学中心支助赠款将提供发展资金，用于植物学方面的培训和推广，并激励新的和现有的教职员工从事植物学研究。本申请请求为中心的管理和组织、规划和评估、共享资源、试点赠款资金以及四个具体项目的资金提供支持：1)异黄酮类与骨质疏松症；2)葡萄多酚与神经保护；3)多酚与癌症；4)多酚与炎症。申请的资金将使普渡大学-阿拉巴马大学植物学中心能够将这些大学的基础研究优势集中在评估植物对健康的影响上。

The proposed Purdue University-University of Alabama at Birmingham (UAB) Botanicals Center is a basic research center that organizes and maintains a multi-disciplinary program for experimental research on botanicals as dietary supplements and serves as national resource on botanical authentication, training, and consumer education. We have a history of strengths in the plant sciences, pharmaceuticals and pharmacognosy, analytical capabilities, biostatistics and human and animal studies on bioavailability and metabolism of dietary constituents. The Center focuses the diverse basic research and education strength of Purdue University and University of Alabama at Birmingham with the clinical support at Purdue University and the General Clinical Research Center at Indiana University School of Medicine on characterizing the active ingrediants in botanicals with an emphasis on polyphenolics and determining their efficacy in reducing risk of age-related diseases including osteoporosis, cancer, cardiovascular disease, and neurodegeneration. To facilitate this research, the Botanicals Center will provide shared resources that include the following Supporting Cores: Administrative and Biostatistical; Botanics and Educational; Analytical: Clinical, Accelerator Mass Spectrometry, and Bioanalytical Systems; and In Vivo Assessment. In additional, the Botanicals Center support grant would provide developmental funds for training and outreach in botanicals and stimulating new and current faculty to engage in botanicals research. This application requests support for the administration and organization of the Center, planning and evaluation, shared resources, pilot grant funds, and funding for four specific projects: 1) Isoflavones and Osteoporosis; 2) Grape Polyphenols and Neuroprotection; 3) Polyphenols and Cancer; and 4) Polyphenols and Inflammation. The requested funds will allow the Purdue University-University of Alabama Botanicals Center to focus the basic research strengths of these Universities on evaluation of the health effects of botanicals.