BOTANICAL CENTER FOR AGE-RELATED DISEASES

拟议中的普渡大学-阿拉巴马大学伯明翰分校（UAB）植物中心是一个基础研究中心，组织和维护一个多学科项目，用于植物制剂作为膳食补充剂的实验研究，并作为国家植物认证、培训和消费者教育的资源。我们在植物科学、制药和生药学、分析能力、生物统计学以及饮食成分生物利用度和代谢的人类和动物研究方面具有悠久的优势。该中心集中了普渡大学和阿拉巴马大学伯明翰分校的多样化基础研究和教育力量，在普渡大学和印第安纳大学医学院的综合临床研究中心的临床支持下，对植物药中的活性成分进行了表征，重点是多酚类物质，并确定了它们在降低骨质疏松症、癌症、心血管疾病和神经退行性疾病等与年龄有关的疾病风险方面的功效。为了促进这项研究，植物中心将提供包括以下支持核心的共享资源：行政和生物统计；植物学和教育；分析：临床，加速器质谱，和生物分析系统；和体内评估。此外，植物中心支持赠款将为植物学培训和推广提供发展资金，并鼓励新的和现有的教员从事植物学研究。本申请要求支持中心的管理和组织、规划和评估、共享资源、试点赠款资金和四个具体项目的资金：1)异黄酮和骨质疏松症；2)葡萄多酚与神经保护作用；3)多酚与癌症；4)多酚和炎症。所申请的资金将允许普渡大学-阿拉巴马大学植物中心将这些大学的基础研究优势集中在评估植物药物对健康的影响上。

The proposed Purdue University-University of Alabama at Birmingham (UAB) Botanicals Center is a basic research center that organizes and maintains a multi-disciplinary program for experimental research on botanicals as dietary supplements and serves as national resource on botanical authentication, training, and consumer education. We have a history of strengths in the plant sciences, pharmaceuticals and pharmacognosy, analytical capabilities, biostatistics and human and animal studies on bioavailability and metabolism of dietary constituents. The Center focuses the diverse basic research and education strength of Purdue University and University of Alabama at Birmingham with the clinical support at Purdue University and the General Clinical Research Center at Indiana University School of Medicine on characterizing the active ingrediants in botanicals with an emphasis on polyphenolics and determining their efficacy in reducing risk of age-related diseases including osteoporosis, cancer, cardiovascular disease, and neurodegeneration. To facilitate this research, the Botanicals Center will provide shared resources that include the following Supporting Cores: Administrative and Biostatistical; Botanics and Educational; Analytical: Clinical, Accelerator Mass Spectrometry, and Bioanalytical Systems; and In Vivo Assessment. In additional, the Botanicals Center support grant would provide developmental funds for training and outreach in botanicals and stimulating new and current faculty to engage in botanicals research. This application requests support for the administration and organization of the Center, planning and evaluation, shared resources, pilot grant funds, and funding for four specific projects: 1) Isoflavones and Osteoporosis; 2) Grape Polyphenols and Neuroprotection; 3) Polyphenols and Cancer; and 4) Polyphenols and Inflammation. The requested funds will allow the Purdue University-University of Alabama Botanicals Center to focus the basic research strengths of these Universities on evaluation of the health effects of botanicals.