UCLA CENTER FOR DIETARY SUPPLEMENTS RESEARCH: BOTANICALS

本申请建议建立UCLA膳食补充剂研究中心：植物制剂（CDSRB），以促进跨学科研究，对植物性膳食补充剂的安全性和有效性进行系统评估。我们汇集了加州大学洛杉矶分校人类营养中心拟议的CDSRB所需的多学科科学专业知识。实现以下具体目标：1)鉴定、表征和鉴定拟作为膳食补充剂使用或已作为膳食补充剂销售的植物制剂；2)评估植物成分的生物利用度和生物活性，包括植物化学标记化合物和/或疑似或已知的活性成分；3)识别植物药物中的有效成分，并探索其在明确生物系统中的作用机制；4)进行细胞培养和动物临床前研究；5)对植物药物进行I期和/或II期临床评估。加州大学洛杉矶分校CHN CDSRB将满足对植物成分生物利用度和生物活性的额外基础和临床研究的关键需求，包括明确定义的生物系统中的植物化学标记化合物和/或生物活性成分，然后将进行动物临床前研究和植物药物的临床I期和/或II期评估。在这份申请中，我们概述了三个发展良好的R01研究项目（中国红曲米、绿茶和圣约翰草），四个试点研究（紫锥菊、黄酮类化合物、大豆异黄酮和植物雌激素），以及农业和植物学、分析植物化学和生物统计学/临床药理学三个科学核心。一个行政和计划核心将管理整个CDSRB，一个新研究者奖和试点研究计划将支持培训和教育倡议，这将开始解决上述许多问题。加州大学洛杉矶分校医学院是美国十大生物医学研究机构之一，将提供丰富的跨学科环境，以实现拟议的植物膳食补充剂研究中心的主要任务。

This application proposes to establish the UCLA Center for Dietary Supplements Research: Botanicals (CDSRB) in order to foster interdisciplinary research to develop systematic evaluation of the safety and efficacy of botanical dietary supplements. We have assembled the multi-disciplinary scientific expertise required for the proposed CDSRB at the UCLA Center for Human Nutrition. to accomplish the following specific aims: 1) Identify, characterize and authenticate botanicals intended for use as dietary supplements or already being sold as dietary supplements; 2) Assess the bioavailability and bioactivity of botanical ingredients including phytochemical marker compounds and/or suspected or known active ingredients; 3) Identify active constituents in botanicals and explore their mechanisms of action in well-defined biological systems; 4) Conduct pre-clinical studies in cell culture and in animals; and 5) Conduct phase I and/or II clinical evaluations of botanicals. The UCLA CHN CDSRB will fulfill the critical need for additional basic and clinical research on the bioavailability and bioactivity of botanical ingredients, including phytochemical marker compounds and/or biologically active constituents in well-defined biological systems and will then conduct pre-clinical studies in animals and clinical phase I and/or II evaluations of botanicals. In this application we outline three well developed R01 Research Projects (Chinese Red Yeast Rice, Green Tea, and St. John's Wort), four Pilot Studies (Echinacea, Flavonoids, Soy Isoflavones, and Plant Phytoestrogens, and three Scientific Cores in Agriculture and Botany, Analytic Phytochemistry, and Biostatistics/Clinical Pharmacology. An Administrative and Planning Core will administer the overall CDSRB, a New Investigator Award and Pilot Study Program support training and educational initiatives which will begin to address many of the issues outlined above. The UCLA School of Medicine is one of the top ten biomedical research institutions in the United States and will provide a rich interdisciplinary environment where the primary mission of the proposed Dietary Supplements Research Center in Botanicals can be achieved.