RESPONSE TO ANTICONVULSANTS IN JUVENILE BIPOLAR DISORDER AS MEASURED BY MRS

1.神经胶质症患者多模式数据库的开发 具有以下领域：a)脑肿瘤的编目和存档 不同患者的冰冻样本。或在相同的时间顺序中 有多个样本的患者，并对患者的临床病理进行分类 通过H和E染色及组织学特征进行诊断 免疫组织化学。b)。基因表达谱编目 应用互补DNA阵列技术冷冻脑瘤标本。c) 分类有关诊断、年龄、功能的临床信息 状态、存活率和对治疗的反应。D)卡他林成像 提供治疗反应和影像特征的数据 图案。 脑胶质瘤基因表达谱分类的研究进展 提供更好的生存预测：a)在组织病理学范围内 B)外部组织病理学--雷德 3.定义基因表达模式，有助于预测反应和 不同治疗方法对恶性血肿患者预后的影响 包括。外科医生--放射治疗。化疗，生物治疗， 免疫疗法。

1. Development of a multimodality database for glionia patients with the following domains: a) cataloging and archiving brain tumor frozen samples in different patients. or chronologically in the same patients with multiple samples, and cataloging the firial pathologic diagnosis, and histologic characteristics through H and E stains and immunohistochemistry . b). cataloging gene expression profiles of frozen brain tumor samples using complementary DNA array . c) cataloging clinical information regarding diagnosis, age, functional status, survival and response to treatment. d) cataio-ine imaging data providing response to treatment and to characterize imaging patterns . I Deveiopment of gene expression pattern classification in gliomas to provide better prediction of survival: a) within histopathologic grade b) outside histopathologic --rade 3. Define gene expression pattern that will help predict response and prognosis in patients with ghoma treated with various therapies including. surgen-, radiation. chemotherapy, biologic therapy, immunotherapy.