ELF5 integrates prolactin and progestin control of mammary gland development via regulation of progenitor cells.

Elf5可能是孕期乳腺细胞生长的主要调节因子。我们将证明Elf5可以取代催乳素和黄体酮来触发乳房发育，我们将确定Elf5作用于干细胞或祖细胞。最后，我们将把这些知识应用于乳腺癌细胞系，以发现Elf5在乳腺癌中的作用。这些实验有可能使Elf5成为治疗乳腺癌的新靶点。

Elf5 may act as a master-regulator of mammary cell growth during pregnancy. We will demonstrate that Elf5 can replace the requirement for prolactin and progesterone to trigger mammary development and we will determine the stem or progenitor cells Elf5 acts on. Finally we will apply this knowledge to breast cancer cell lines to discover what role Elf5 plays in breast cancer. These experiments have the potential to establish Elf5 as a new therapeutic target for the treatment of breast cancer.