Diagnostic Electron Microscopy (EM)

透射电子显微镜（EM）被用作一种辅助程序，在广泛的肿瘤性和非肿瘤性疾病的诊断，可以是非常有用的选择诊断困境。诊断电子显微镜服务的主要目标是：(1)为NCI和NIH支持的临床诊断和治疗方案提供高质量的电子显微镜诊断服务；(2)帮助阐明这些方案中研究的疾病过程的发病机制；(3)向病理学住院医师和研究员传授电子显微镜在人类疾病诊断中的应用；(4)向NIH科学界提供电子显微镜专业知识。去年的成就总结如下：

Transmission electron microscopy (EM) is used as an adjunct procedure in the diagnosis of a wide range of neoplastic and non neoplastic diseases and can be extremely useful in well chosen diagnostic dilemmas. The main objectives of the diagnostic EM service are: (1) to provide high quality EM diagnostic services to NCI- and NIH-supported clinical diagnostic and treatment protocols (2) to help elucidate the pathogenesis of disease processes studied in these protocols (3) to teach pathology residents and fellows the application of EM in the diagnosis of human diseases and (4) to provide electron microscopic expertise to the NIH scientific community. The last year's accomplishments are summarized below: (1) A total of 100 patient tissues were processed and diagnosed by EM. The service is regularly inspected and certified by CAP. (2) Research specimens with multiple samples per specimen were processed and evaluated, resulting in 7 publications. (3) Invitation by the Society of Ultrastructural Pathology to lecture in the society's companion meeting on "the routine use of electron microscopy and other adjunct diagnostic techniques in pediatric neoplasms" (US-CAP meeting, Chicago, Feb. 24, 2002)