MECHANISMS OF HIV INFECTION IN THE ORAL MUCOSA

请求通过查尔斯·R·德鲁医学和科学大学少数民族机构研究中心(RCMI)支持建立一个临床卓越研究中心。该中心名为“糖尿病和新陈代谢城市研究和教育中心”(CUREDM)，旨在吸引一位拥有独立研究支持的知名研究人员，并为研究糖尿病、胰岛素抵抗状态、高胆固醇血症、肥胖、激素失调和其他代谢相关疾病的研究人员提供研究资源。这些资源将包括开发两个核心设施，并辅之以一个发展项目。CUREDM将通过其独立研究和指导初级调查人员的能力来增强和加强DREW的临床研究能力。按照这一申请的要求，农村妇女保健委员会将解决对RCMI机构所服务的土著人口影响过大的保健问题，并将这些问题视为国家保健优先事项。德鲁大学独特的患者群体由大约55%的西班牙裔、35%的非裔美国人和10%的亚洲/太平洋岛民组成，他们患有不成比例的糖尿病和代谢相关疾病。在过去的4年里，德鲁经历了临床研究基础设施的逐步加强，越来越多的研究人员对糖尿病和代谢相关疾病的研究感兴趣和活跃。这创造了一个适当的专业互动和成长环境，将有助于招聘一名高素质的调查员来指导CUREDM。因此，德鲁是建立CUREDM的理想地点。尽管在缺乏服务的人群中糖尿病和代谢紊乱的患病率特别高，但这些紊乱在我们的社会中普遍存在，从CUREDM获得的信息可能会为改善国家的医疗保健做出重要贡献。

Support is requested to establish a Clinical Center of Research Excellence through the Research Center for Minority Institutions (RCMI) at the Charles R. Drew University of Medicine and Science (Drew). This center, entitled "The Center of Urban Research and Education in Diabetes and Metabolism" (CUREDM), is designed to attract an established research investigator with independent research support and provide research resources for investigators who will study diabetes, insulin resistance states, hypercholesterolemia, obesity, hormonal dysregulation and other metabolic related diseases. These resources will include the development of two core facilities complemented by a developmental project. CUREDM will augment and strengthen Drew's clinical research capabilities through its independent research and its ability to mentor junior investigators. Consistent with the request for this application CUREDM will address health care issues that disproportionately affect the indigenous populations served by the RCMI institutions and are recognized as national health care priorities. The unique patient population at Drew University is comprised of approximately 55 percent Hispanic, 35 percent African Americans, and 10 percent Asian/Pacific Islander who suffer disproportionately from diabetes and metabolic related disorders. Over the last 4 years Drew has experienced a progressive enhancement in the clinical research infrastructure and an increasing number of investigators with research interest and activity in diabetes and metabolic related diseases. This creates an appropriate environment of professional interaction and growth that will facilitate the recruitment of a highly qualified investigator to direct CUREDM. Thus, Drew is an ideal location for the establishment of CUREDM. Although there is a particularly high prevalence of diabetes and metabolic disorders in underserved populations, these disorders are pervasive in our society and information gained from CUREDM is likely to yield important contributions toward improving health care for the nation.