RESOURCE FACILITY FOR POPULATION KINETICS

这项建议是为了建立人口资源基金 动力学(RFPK)。RFPK的目的将是促进应用 以隔室为中心的生物医学研究中的计算机建模 种群动力学。 用于量化研究对象间的方法中的总体动力学 动力学研究中的可变性。广泛应用于药代动力学研究。 研究，因为它是了解药物在体内的作用的关键 人类和动物。在代谢(例如示踪剂)动力学研究中，它被使用 要识别模型中在比较两个参数时发生更改的参数 人口。越来越多的研究人员认识到 软件工具在这一领域的重要性以及个人的需求 拥有开发和应用它们的专业知识。RFPK将提供这一点 作为实现其目标的一部分的专门知识：(1)发展 以及建模技术在生物医学问题中的应用，92) 开发种群动力学的通用算法，以及 通过图形开发使这些算法易于使用 用于分区模型的用户界面，(3)支持协作 帮助设计和应用软件工具的项目， (4)为我们的用户社区提供服务和培训，以及(5) 传播我们的技术、专业知识和成就。 拟议的软件工具将以模块化方式设计。 一些模块将向其他软件开发人员提供，因此 扩大新计算能力的应用领域。 软件工具将分阶段开发和发布，以便用户 可以开始应用该技术，并为未来提供反馈 事态的发展。这些工具的独特之处在于，没有人 该软件包提供了简单的建模能力和 标准种群动力学方法：参数、非参数和 两个阶段。因此，软件工具将极大地提高整体 所有类型的动力学研究的研究质量。 RFPK在两所主要大学分发，这两所大学都做出了贡献 该项目拥有独特的专业知识。管理核心位于 华盛顿大学。

This proposal is to establish the Resource Facility for Population Kinetics (RFPK). The purpose of RFPK will be to promote the application of computer modeling in biomedical research focusing on compartmental population kinetics. Population kinetics in the methodology used to quantify inter-subject variability in kinetic studies. It is widely used in pharmacokinetic studies since it is the key to the understanding of how drugs behave in humans and animals. In metabolic (e.g. tracer) kinetic studies, it is used to identify those parameters in a model which change when comparing two populations. A growing number of researchers are recognizing the importance of software tools in this area and the need for individuals with the expertise to develop and apply them. RFPK will provide that expertise as part of fulfilling its goals which are: (1) the development and application of modeling technology to biomedical problems, 92) the development of general purpose algorithms for population kinetics, and making these algorithms easy to use through the development of graphical user interfaces for compartmental models, (3) supporting collaborative projects which help in the design and application of the software tools, (4) providing service and training to our user community, and (5) disseminating our technology, expertise and accomplishments. The proposed software tools will be designed in a modularized fashion. Some modules will be made available to other software developers thus extending the areas of application of the new computational capabilities. The software tools will be developed and released in stages so that users can start applying the technology and give feedback for future developments. What will make these tools unique is that there is no one software package that provide both easy model building capacity and the standard population kinetic methodologies: parametric, non-parametric, and two-stage. Thus the software tools will greatly enhance the overall quality of research in all types of kinetic studies. RFPK is distributed at two major universities both of whom contribute unique expertise to the project. The Administrative Core is located at the University of Washington.