Energy Balance and Breast Cancer in Black & White Women

描述（由申请人提供）：我寻求五年的资金来发展 癌症流行病学的研究和教学技能，并获得有针对性的 能量代谢、癌症生物学和乳房生理学的培训， 将这些学科与黑人乳腺癌的流行病学结合起来， 和白色女人。一个在所有领域都具有广泛技能和经验的指导团队 这些学科将有助于指导我的学术和教学发展。我 博士在流行病学集中在生殖健康，我已经完成了一个 癌症流行病学和癌症预防研究金 遗传学，国家癌症研究所。我是一个终身制助理教授， MSU的流行病学。提出了三个研究项目， 能量平衡和胰岛素抵抗相关因素与糖尿病的关系 美国黑人和白色妇女乳腺癌的年龄特异性发病率 美国的第一个使用的数据来自前瞻性乳腺癌 检测项目（BCDDP）队列研究，以检查身体大小的关联 在不同的年龄，糖尿病和饮食模式与胰岛素相关 女性乳腺癌的发病率与耐药性有关。第二个项目 使用来自儿童饮食干预研究（DISC）的数据， 在8-10岁的女孩中进行饮食干预临床试验，以检查 饮食对血清胰岛素、IGF-1和瘦素影响。了解 在青春期影响这些因素的机制，可能特别是 与了解以后患乳腺癌的风险有关。第三个项目将是 一项病例对照研究的试点研究，以检查能量与 平衡和胰岛素抵抗相关因素与底特律SEER登记区黑人和白色妇女乳腺癌发病率的关系。有效 癌症预防需要多学科的方法， 了解疾病和桥梁的分子和社会背景 实验室和社会科学家之间的差距。MSU及周边 机构，与外部顾问合作，提供一个优秀的 环境，让我发展我的技能，并获得额外的专业知识， 有效整合癌症流行病学的多学科方法， 预防

DESCRIPTION (provided by applicant): I seek five years of funding to develop research and teaching skills in cancer epidemiology and to obtain targeted training in energy metabolism, cancer biology, and breast physiology in order to integrate these disciplines with the epidemiology of breast cancer in black and white women. A mentoring team with extensive skills and experience in all of these disciplines will help guide my academic and teaching development. My Ph.D. in Epidemiology focused on reproductive health, and I have completed a Cancer Prevention Fellowship in the Division of Cancer Epidemiology and Genetics, NCI. I am a tenure-track Assistant Professor in the Department of Epidemiology at MSU. Three research projects are proposed that investigate the relationship of energy balance and insulin resistance-related factors with the age-specific incidence of breast cancer in black and white women in the United States. The first uses data from the prospective Breast Cancer Detection Project (BCDDP) cohort study to examine the association of body size at different ages, diabetes, and dietary patterns related to insulin resistance, with the incidence of breast cancer in women. The second project uses data from the Dietary Intervention Study in Children (DISC), a low-fat dietary intervention clinical trial in girls 8-10 years of age, to examine the effect of diet on serum insulin, IGF-1 and leptin. Understanding the mechanisms that affect these factors in adolescence, may be particularly relevant to understanding later breast cancer risk. The third project will be a pilot study for a case-control study to examine the association of energy balance and insulin resistance-related factors with the incidence of breast cancer in black and white women in the Detroit SEER registry area. Effective cancer prevention requires a multidisciplinary approach that incorporates an understanding of both the molecular and social contexts of disease and bridges the gap between laboratory and social scientists. MSU and surrounding institutions, in collaboration with external advisors, offer an excellent environment for me to develop my skills and gain additional expertise to effectively integrate a multidisciplinary approach to cancer epidemiology and prevention.