PREVENTIVE ONCOLOGY ACADEMIC AWARD

描述：（申请人的描述）建议的计划将为我提供 在癌症流行病学方面有着长期职业生涯的基础， 预防 实现这一目标的途径是熟练掌握 分子流行病学，它有希望推进我们的知识， 癌症病因学以及癌症预防，增加了我的既定技能 流行病学方法。 教育和研究双管齐下 本文提出 该教育计划旨在：1）扩展我的分子知识 流行病学和2）提高我的教学和沟通技巧。 的 前一个目标将通过课程工作，讨论为导向 论坛，并通过研究计划得到加强。 为了实现后一个目标， 我将参加有关流行病学方法和癌症的教学课程 流行病学 我还将在社区工作，以提高技能， 与决策者沟通。 该研究计划包括三项研究，重点是结肠癌。 1期是一项前瞻性队列研究，研究吸烟与 结肠癌的风险。 2期是一项嵌套病例对照研究， 评估吸烟、饮食和基因多态性之间的关系， 编码与结肠相关的致癌物代谢酶的基因 癌症风险。 3期是一项横断面研究， 生活方式和预防癌症的行为，这将导致 制定癌症控制计划。 这项研究计划的结果， 虽然有助于我们了解结肠癌的病因， 适用的易感人群亚组， 风险 通过加强我在分子流行病学方面的背景， 将建立在以前的癌症流行病学和预防经验的基础上 并将使我能够从事广泛的研究， 预防癌症。

DESCRIPTION: (Applicant's Description) The proposed plan will provide me with a foundation for a long-term career in cancer epidemiology and prevention. The pathway outlined toward this goal is to gain proficiency in molecular epidemiology, which holds promise to advance our knowledge of both cancer etiology as well as cancer prevention, adding to my established skill in epidemiologic methods. A two-pronged approach of education and research is proposed. The educational plan is designed to: 1) expand my knowledge of molecular epidemiology and 2) enhance my teaching and communication skills. The former goal will be addressed through course work, discussion-oriented forums, and be reinforced by the research program. Toward the latter goal, I will participate in teaching classes on epidemiologic methods and cancer epidemiology. I will also work in community setting to enhance skills in communicating with decision-makers. The research plan consists of three studies with a focus on colon cancer. Phase 1 is a prospective cohort study of cigarette smoking in relation to the risk of colon cancer. Phase 2 is a nested case control study to evaluate the relationships of cigarette smoking, diet, and polymorphisms in genes that encode carcinogen metabolizing enzymes in relation to colon cancer risk. Phase 3 is a cross-sectional study of the prevalence of lifestyle practices and cancer prevention behaviors that will lead to the development of a cancer control plan. The results of this research program, while contributing to our knowledge of the etiology of colon cancer, will be applicable susceptible subgroups of the population who may be at greatest risk. By strengthening my background in molecular epidemiology, the proposal plan will build upon previous experience in cancer epidemiology and prevention and will enable me to engage in a broad range of research geared toward the prevention of cancer.