CORE--EXPOSURE ANALYSIS AND HEALTH EFFECTS

暴露分析和健康影响的研究核心是 旨在提供开发和利用 表征暴露的科学和临床方法， 环境污染物对健康的影响。这个核心已经改名了 自上一个审议周期以来进行了部分重组并扩大了范围。的 名称的变化反映了工作范围的扩大，包括临床研究 除了环境流行病学之外，还放置了 更加重视旨在确定暴露生物标志物的研究。 纳入旧的流行病学方法活动 建模与流行病学研究实验室成新的统计支撑 设施核心实验室，建立照射和剂量测定实验室 核心实验室和新的临床核心设施的开发， 部分重组。这一核心的具体目标代表了 上一个审查周期的变化和修改。既定目标 包括：1）开发接触机制和诊断模型， 药代动力学，以估计目标接受的毒性剂的剂量 人口、个人或器官; 2）开发和使用分析技术 其可以测量无机/无机化学物质和/或生物标记物 在受控和现场情况下的暴露; 3）设计和进行人类 在受控和实地研究中对有毒物剂的预防-反应研究; 4)设计和开展关于环境暴露的流行病学研究， 健康影响; 5）开展生理和心理的临床研究 暴露于环境压力源的结果的预测因子。这些 重新制定的对象反映了这一核心计划，以扩大其工作， 现场使用的暴露生物标志物的开发和验证 研究（环境流行病学和人口接触评估）和 受控实验室/环境人类研究。这些新目标还 强调核心计划制定一个控制人类暴露的计划 研究中，敏感和正常受试者将暴露于不同水平的 环境室研究中的单一化合物和复杂混合物， 结果评估包括：暴露生物标志物，效应生物标志物， 生理效应和心理或心理物理效应。

The Research Core on Exposure Analysis and Health Effects is directed toward providing expertise in the development and utilization of scientific and clinical approaches to the characterization of exposures and health effects of environmental contaminants. This core has been renamed, partially reorganized and broaden in scope since the last review cycle. The name change reflects expanding the scope of work to include clinical studies in addition to environmental epidemiology, as well as the placement of a greater emphasis on research directed at identifying biomarkers of exposure. Incorporation of epidemiologic methods activities from the old Exposure Modeling and Epidemiologic Research Laboratory into a new Statistical Support Facility Core Laboratory, establishment of a Exposure and Dosimetry Laboratory Core Laboratory and development of a new Clinical Core Facility has resulted in the partial reorganization. The specific goals of this core represent both changes and modifications from the previous review cycle. The stated goals include: 1) developing mechanistic and diagnostic models of exposure and pharmacokinetics to estimate dose of a toxic agent received by a target population, individual or organ; 2) develop and employ analytical techniques which can measure inorganic/inorganic chemical species and/or biologic markers of exposure in controlled and field situations; 3) design and conduct human exposure-response studies of toxic agents in controlled and field studies; 4) design and conduct epidemiologic research on environmental exposures and health effects; 5) develop clinical studies of physiological and psychological predictors of outcomes from exposures to environmental stressors. These reformulated objects reflect this cores plans to expand its work into the development and validations of biological markers of exposure for use in field studies (environmental epidemiologic and population exposure assessment) and controlled laboratory/environmental human studies. These new objectives also highlight the cores plans to develop a program of controlled human exposures studies, where sensitive and normal subjects will be exposed to varying levels of single compounds and complex mixtures in environmental chamber studies with outcome assessments to include: biomarkers of exposure, biomarkers of effect, physiological effects and psychological or psychophysical effects.