Core--Osteotoxicology

骨毒理学研究核心是EHSC的新成员。 此核心的目标是生成有关环境如何、 职业性和外来物对骨骼组织的不利影响，以及如何 这些影响会影响生活质量。这一提议的核心有五个 调查人员，他们都是EHSC的新手。五大工程 在核心围绕以下主题：1)成人骨骼的毒理学； 2)发育中骨骼的毒理学；以及，3)毒理学效应 口腔生物学中的金属。具体而言，这些项目包括： 1)铅对体外骨重建的影响(Puzas博士，与 奥基夫博士、希克斯博士和庞德博士)；2)铅诱导的动物模型 骨质疏松症(Puzas和Pound博士，Cory-Slechta博士)；3) 种植体周围骨溶解中的异物磨屑(O？Keefe博士，与 Puzas和Hicks博士)；4)铅对生长板软骨细胞的影响 (希克斯博士、普扎斯博士、奥基夫博士和科里-斯莱克塔博士)；5)环境 龋齿的影响(鲍文博士，与普扎斯博士，庞德，克拉克森)。

The Osteotoxicology Research Core is a new addition to the EHSC. The goal of this Core is to generate basic information on how environmental, occupational, and foreign agents adversely affect skeletal tissues, and how these effects impact quality of life. This proposed Core has five investigators, all of whom are new to the EHSC. The five major projects within the Core surround the themes of: 1) toxicology of the adult skeleton; 2) toxicology of the developing skeleton; and, 3) toxicological effects of metals in oral biology. Specifically, these projects include the following: 1) the effects of lead on bone remodeling in vitro (Dr. Puzas, with Drs. O?Keefe, Hicks, and Pounds); 2) animal models of lead-induced osteoporosis (Drs. Puzas and Pounds, with Dr. Cory-Slechta); 3) the effect of foreign wear debris in osteolysis around implants (Dr. O?Keefe, with Drs. Puzas and Hicks); 4) effect of lead on growth plate chondrocytes (Dr. Hicks, with Drs. Puzas, O?Keefe, and Cory-Slechta); 5) environmental influences of dental caries (Dr. Bowen, with Drs. Puzas, Pounds, Clarkson).