Development and Neural Bases of Sequence Learning

描述（由申请人提供）：修订后的研究职业奖 申请将为申请人提供额外的培训和 使用职能来追求独立职业所必需的指导 神经影像技术检查发育认知问题 神经科学。申请人是精神病学心理学讲师 儿童心理学博士培训和解剖学博士后培训 以及针对儿童的功能性磁共振成像 (MRI) 技术。她的 工作重点是整个童年时期学习和记忆技能的大脑基础， 特别是内隐序列学习的发展。目前的 该提案旨在以这种发展专业知识为基础，并进一步推动 候选人在认知科学和先进技术方面的理论思维 功能性 MRI 领域的技能以及行为、 电生理学和功能磁共振成像方法来检查神经基础 儿童的顺序学习。她将在设计、行为和 对试图弥补差距的行为和神经影像学研究进行分析 研究内隐学习的发展和神经基础的文献 跨越童年。研究将涉及规范发展，包括 1）开发基于眼动的序列学习任务 适合所有年龄段； 2) 探究行为的实验 通过操纵儿童学习系统的特征来限制儿童学习系统 要学习的信息，以及3）并行电生理学和 神经影像研究评估神经的时间和空间动态 系统在整个发展过程中促进序列学习。总体目的 拟议的研究是为了进一步我们对神经系统的理解 各种形式的学习和记忆的发展的基础。最终， 这项工作的长期目标是为 了解这些神经系统发育的破坏如何可能 导致发育障碍。

DESCRIPTION (provided by applicant): This revised Research Career Award application will provide the applicant with the additional training and mentoring necessary to pursue an independent career using functional neuroimaging techniques to examine issues in developmental cognitive neuroscience. The applicant is an Instructor of Psychology in Psychiatry with doctoral training in child psychology and postdoctoral training in anatomical and functional magnetic resonance imaging (MRI) techniques with children. Her work focuses on the brain bases of learning and memory skills across childhood, in particular, the development of implicit sequence learning. The current proposal seeks to build on this developmental expertise and to further the candidate's theoretical thinking in cognitive science and advanced technical skills in the area of functional MRI, and the integration of behavioral, electrophysiological and fMRI approaches to examining the neural bases of sequence learning in children. She will be mentored in the design, conduct, and analysis of behavioral and neuroimaging studies that attempt to address gaps in the literature examining the development and neural bases of implicit learning across childhood. Studies will address normative development and will include 1) development of an eye movement based sequence learning task that is appropriate for all age ranges; 2) behavioral experiments that probe the constraints of child learning systems by manipulating characteristics of the information to be learned, and 3) parallel electrophysiological and neuroimaging studies to assess the temporal and spatial dynamics of the neural systems subserving sequence learning across development. The overall purpose of the proposedstudies is to further our understanding of the neural systems underlying the development of various forms of learning and memory. Ultimately, the long-term goal of this work is to lay the critical foundation for understanding how disruptions in the development of these neural systems may give rise to developmental disorders.