Quantification of Regional coronary Blood Flow

描述（来自申请人摘要的逐字记录）：最近的研究 强调了传统冠状动脉造影的局限性。这些 局限性包括较大的观察者内和观察者间变异性， 结果来自冠状动脉狭窄病变的主观视觉分级。 此外，病理结果显示， 根据冠状动脉造影估计冠状动脉狭窄的严重程度， 在死后心脏中测量的狭窄病变的实际严重程度。因为 标准冠状动脉造影的主要局限性， 狭窄严重程度的测量，例如局部冠状动脉血流的测量 可在心导管插入术期间获得。血流 测量将提供有价值的功能信息，除了 在常规冠状动脉造影中获得的解剖数据。的目的 这项研究计划是发展一种技术， 三维冠状动脉血流的首过分布算法 冠状动脉树重建及其在心脏手术中的应用 导管插入实验室具体而言，其目的是：（1）核查 局部心肌质量与动脉血流量之和的线性关系 使用猪的冠状血管树中任何点远端的分支长度 动物模型(2)对规范化区域经济增长假设的调查 可以利用第一遍进行冠状动脉血流测量 分布分析技术结合动脉分支总数 冠状动脉树的三维重建。(3)调查 标准化的局部冠状动脉血流测量可以 用于评估不同大小灌注的冠状动脉狭窄程度 床(4)局部冠状动脉血流测量的实现 心脏导管插入术实验室中用于人体研究的技术。的 这项研究的结果将提供改进的生理方法， 量化患者冠状动脉狭窄的严重程度。该量化 技术可用于测量患者的局部心肌灌注 接受标准冠状动脉造影

DESCRIPTION (Verbatim from the Applicant's Abstract): Recent studies have emphasized the limitations of conventional coronary arteriography. These limitations include the large intraobserver and interobserver variability that result from subjective visual grading of coronary stenotic lesions. Furthermore, pathologic findings have shown a lack of correlation between the severity of coronary stenosis as estimated from coronary arteriogram and the actual severity of stenotic lesions measured in postmortem hearts. Because of the major limitations of standard coronary arteriography, a functional measure of stenosis severity such as measurement of regional coronary blood flow obtainable during cardiac catheterization is desirable. The blood flow measurement would provide valuable functional information in addition to the anatomical data obtained during routine coronary arteriography. The purpose of this research plan is to develop of a technique for quantification regional coronary blood flow by combining the first pass distribution algorithm with 3-D reconstruction of coronary artery tree and its implementation in the cardiac catheterization laboratory. More specifically, the aims are: (1) Verification of the linear relation between regional myocardial mass and the sum of arterial branch lengths distal to any point in the coronary vascular tree using a swine animal model. (2) Investigation of the hypothesis that normalized regional coronary blood flow measurement can be made utilizing the first pass distribution analysis technique in conjunction with the sum of arterial branch lengths using 3-D reconstruction of coronary artery tree. (3) Investigation of the hypothesis that normalized regional coronary blood flow measurement can be used to assess coronary artery stenosis severity in different size perfusion beds. (4) Implementation of the regional coronary blood flow measurement technique in the cardiac catheterization laboratory for human studies. The results of this research will provide improved physiological methods of quantitating coronary artery stenosis severity in patients. This quantification technique could be used to measure regional myocardial perfusion in patients undergoing standard coronary arteriography.