RESEARCH TRAINING IN AGING CARDIOVASCULAR PHYSIOLOGY

这个职业生涯中期以病人为导向的研究奖的具体目标 （1）进一步确立候选人的独立性- 衰老的神经体液机制的临床研究计划 心血管生理学，和20提供候选人的时间和 为进修临床医学课程的学员提供导师服务所需的资源 衰老心血管生理学研究。候选人有一个 在患者中持续资助的生产性研究记录- 从这个奖学金培训开始， 从1985年到现在的老年医学。候选人的病人- 导向研究计划是资助的作用，同情 神经系统（SNS）和其他神经体液系统在调节 血压和心脏收缩力在正常人老化， 老年高血压和心力衰竭患者。保护时间 该奖项将允许候选人进一步发展 新的方法来评估调节SNS活动，肾上腺素能 老年患者的受体功能和其他神经体液机制 患有高血压和心力衰竭候选人有既定的 为博士前和博士后学员提供导师的记录。的 候选人的研究计划将提供背景，使他能够 继续培训临床研究人员。候选人的 研究计划和对指导的承诺将得到补充， 特殊的研究和培训计划的大学的优势 Michigan（UM）.这些项目包括杰出的临床研究 在一个资金充足的综合临床研究中心的设施，资源 由几个主要的研究中心提供（例如Claude Peppers 老年医学中心，老年学和老年医学研究所， 教育和临床中心在安阿伯弗吉尼亚州），和优秀的 教育资源，通过课程的UM综合 老年医学奖学金计划和科学公共卫生学院 临床研究设计和统计分析程序。最后， 正在制定新的举措，以促进创新的临床 研究和临床研究者在UM的培训（例如， 临床研究中心和临床培训 UM的研究者（例如临床研究中心和 治疗学）。总之，候选人在病人方面的成就- 他的能力和承诺，指导临床 研究员学员，以及澳门大学的研究和培训优势 联合收割机提供了一个理想的环境，以实现特定的目标， 这个提议。

The specific aims of this mid-career patient-oriented research award are: 1) to further establish the candidate's independent patient- oriented clinical research program in neurohumoral mechanisms of aging cardiovascular physiology, and 20 to provide the candidate the time and resources necessary to provide mentorship to trainees pursuing clinical investigation of aging cardiovascular physiology. The candidate has a record of continuously funded productive investigation in patient- oriented research dating from the beginning of this fellowship training in Geriatric Medicine in 1985 to the present. The candidate's patient- oriented research program is funded on the role of the sympathetic nervous system (SNS) and other neurohumoral systems in the regulation of blood pressure and cardiac contractility in normal human aging, and in older patients with hypertension and heart failure. The protected time afforded by this award will permit the candidate to further develop novel methods to assess the regulation of SNS activity, adrenergic receptor function and other neurohumoral mechanisms in older patients with hypertension and heart failure. The candidate has an established record of providing mentorship of pre- and post-doctoral trainees. The candidate's research program will provide the context to permit him to continue training beginning clinical investigators. The candidate's research program and commitment to mentoring will be complemented by the special research and training program strengths of the University of Michigan (UM). These programs include outstanding clinical research facilities in a well-funded General Clinical Research Center, resource provided by several major research centers (e.g. Claude Peppers Geriatrics Center, Institute of Gerontology and Geriatric Research, Education, and Clinical Center at the Ann Arbor VA), and excellent educational resources through the curricula of the UM integrated Geriatric Fellowship Program and the School of Public Health of Science Program in Clinical Research Design and Statistical Analysis. Finally, new initiatives are being developed to facilitate innovative clinical investigation and the training of clinical investigators at the UM (e.g. the Center for Clinical Investigation and the training of clinical investigators at the UM (e.g. the Center for Clinical Investigation and Therapeutics). In summary, the candidate's accomplishment in patient- oriented research, his ability and commitment to mentor clinical investigator trainees, and the research and training strengths of the UM combine to provide an ideal context to accomplish the specific aims of this proposal.