Helix Packing and Ligand Binding in Dopamine Receptors

描述(出自申请者S摘要)： 这是一个应用专业计算的博士后NRSA应用程序 研究多巴胺受体结构的方法。三度空间 G蛋白偶联受体的结构尚不清楚，因为没有 它们已经成功地结晶出来。然而，视紫红质一直是 结晶，尽管只有在相对较低的分辨率。候选人将会 利用了一系列在 赞助？S实验室获取多巴胺受体的结构信息 在原子水平上，使用来自视紫红质的已知结构信息作为 导游。这些分析将从跨膜片段开始，然后继续进行 分析多巴胺配体结合区的潜在结构 受体类型。

DESCRIPTION (From applicant?s abstract): This is a postdoctoral NRSA application to apply specialized computational approaches to study the structure of dopamine receptors. The three-dimensional structures of G-protein-coupled receptors are not yet known because none of them have been successfully crystallized. However, rhodopsin has been crystallized, although only at relatively low resolution. The candidate will utilize a series of potential energy screening algorithms developed in the sponsor?s laboratory to achieve structural information about dopamine receptors at the atomic level, using known structural information from rhodopsin as a guide. These analyses would begin with the transmembrane segments, then proceed to analyze the potential structure of ligand binding domains of dopamine receptor types.