INHALED NITRIC OXIDE

该提案是一项原始赠款的竞争性延续 这导致了吸入性一氧化氮（NO）用于 肺动脉高压的治疗。吸入NO会产生选择性的 肺血管扩张在通风肺泡中，约60%的个体没有 导致动脉血氧饱和度下降。然而，40%的患者没有 研究人员将研究氧自由基的作用， 类花生酸对NO的低反应性。它们将决定 对NO反应性的丧失和缺氧性肺动脉收缩功能的丧失 血管收缩（HPV）在脓毒症，特别是因为它可能与诱导型NO 合成酶最后，他们将研究吸入疗法， 影响HPV，看看它们是否能有效增强绵羊的气体交换， 小鼠肺损伤模型。

The proposal is a competitive continuation of an original grant that has led to the clinical application of inhaled nitric oxide (NO) for the treatment of pulmonary hypertension. Inhaled NO will produce selective pulmonary vasodilation IN VENTILATED alveoli in some 60% of individuals without causing a fall in arterial oxygen saturation. However, 40% of patients do noT responD to NO. The investigators will study the roles of oxygen radicals and eicosanoids in hyporesponsiveness to NO. They will determine the relationship of loss of responsiveness to NO and the loss of hypoxic pulmonary vasoconstriction (HPV) in sepsis, especially as it may relate to inducible No synthase. Lastly, they will study inhalation therapy with agents that do not affect HPV and see if they are effective in enhancing gas exchange in ovine and murine lung injury models.