Electrochemical Flow Reactors in High Value Chemical Manufacturing

研究背景：在过去的20年里，电化学在合成有机化学方法方面取得了长足的进步。它允许化学家在不使用昂贵且往往有毒的金属催化剂的情况下进行困难的化学反应。尽管如此，标准化的反应器和技术仍然是阻碍这些反应在合成过程中广泛发展和应用的主要障碍。目的和目标：本项目将开发标准化和开放式的电化学流反应器(EFRs)，用于有机反应。一旦建成和验证，这些反应器将用于开发一系列对合成具有重要意义的三种新型反应：(I)C-H活化/胺化，(Ii)催化Wittig反应，和(Iii)Ni(Iii)催化的偶联反应。潜在的应用和好处：该项目提供以下好处：(I)使技术能够促进电化学反应在更广泛的学术界和工业界的发展和采用；(Ii)更可持续的工艺，产品提纯更简单，浪费更少，更容易放大；(Iii)将对合成技术产生重大影响的重要的新型反应。研究领域：流动化学、电化学--需取得有机化学博士学位

Context of research: Electrochemistry has made substantial advances in synthetic organic chemistry methods over the past 20 years. It has allowed chemists to run difficult chemical reactions without the use of expensive, and often toxic, metal catalysts. Despite these, standardised reactors and techniques are still the major obstacles preventing wider development and application of these reactions in synthetic processes.Aims and objectives: In this project, standardised and open-access electrochemical flow reactors (EFRs) will be developed for application in organic reactions. Once built and validated, the reactors will be used to develop a series of three novel reactions with significant synthetic importance: (i) C-H activation/amination, (ii) catalytic Wittig reaction, and (iii) Ni(III) catalysed coupling reaction.Potential applications and benefits: The project delivers the following benefits: (i) enabling technology to facilitate development and adoption of electrochemical reaction in synthetic science in wider academia and industry; (ii) more sustainable processes with simpler product purification, less waste, and easier to scale-up; (iii) important novel reactions which will have significant impact in synthetic technology. Research areas: Flow chemistry, electrochemistryQualification to be attained: PhD degree in Organic Chemistry