Molecular/Biologic/Genetic Mechanisms of Ovarian Cancer

描述（由申请人提供）： 本次研讨会的目的是了解遗传和生物学 参与卵巢癌的机制以及这些机制如何 利用这一机会制定创新的预防、检测和筛查战略。 它将进一步探讨这些模式对妇女生活的影响 和他们的家人 随着分子生物学的进步和 新技术（例如，蛋白质组学，基因组学），我们正在收集显着的 了解致癌的遗传和生物学基础。 通过直接 促进我们对疾病过程的理解，这些知识和 技术正在提出富有成效的预防、检测和 筛查进展 该论坛将汇集预防、 检测和筛选研究，以交流他们的专业知识， 确定研究途径并形成合作。 研讨会将在 2002年5月6日至7日，匹兹堡大学癌症研究所，Magee-Womens 医院所在地，NCI综合癌症中心和美国6个健康和 人类服务国家妇女健康卓越中心。 预期 观众是基础，临床和翻译研究人员在该领域的 流行病学，分子生物学，遗传学，细胞生物学，内分泌学， 病理学、妇科肿瘤学和高通量技术， 强调卵巢癌，以及公共卫生研究人员和消费者 律师 研讨会的具体目标包括：1。进一步 了解卵巢癌的分子、生物学和遗传机制， 癌症的发展以及这些机制如何成为预防的目标， 检测和筛选; 2.熟悉新兴的化学预防 针对分子靶点的药物和早期检测方法; 3.学习 关于新的高通量技术及其在卵巢癌中的应用 研究; 4.基于分子生物学的新研究领域， 疾病的机制;和5。去理解这些 关于高危妇女健康和公共政策的模式。 主题 包括：流行病学;早期发现、预防和筛查;新 技术;外科和化学预防;身体、社会和 预防、筛查和遗传学的心理影响;以及 消费者/公共政策视角。 所有会议都包括一个讨论， 领导在外地。 到目前为止，还没有专门的讲习班， 专注于卵巢癌和分子靶点的交叉点;也没有 没有任何关于高危妇女、健康影响和公共政策的报告。 这 研讨会是一个独特的机会，汇集科学家，政策制定者， 研究人员和消费者倡导者推动卵巢癌的前沿 研究和公共卫生。

DESCRIPTION (provided by applicant): The goal of this symposium is to understand the genetic and biologic mechanisms involved in ovarian cancer and how these mechanisms can be exploited to devise innovative prevention, detection and screening strategies. It will further address the impact of these modalities on the lives of women and their families. With advances in molecular biology and the emergence of new technologies (e.g., proteomics, genomics), we are gathering remarkable knowledge about the genetic and biologic basis of carcinogenesis. By directly facilitating our understanding of the disease process, this knowledge and technology is suggesting fruitful avenues of prevention, detection and screening advances. This forum will bring together leaders in prevention, detection and screening research in order to exchange their expertise, identify research avenues and form collaborations. The symposium will be held May 6-7, 2002 at the University of Pittsburgh Cancer Institute, Magee-Womens Hospital site, an NCI Comprehensive Cancer Center and one of 6 US Health and Human Services National Centers of Excellence in Women's Health. The intended audience is basic, clinical and translational researchers in the areas of epidemiology, molecular biology, genetics, cell biology, endocrinology, pathology, gynecologic oncology, and high-throughput technologies, with an emphasis on ovarian cancer, as well as public health researchers and consumer advocates. The specific goals of the workshop include: 1. to further understand the molecular, biologic and genetic mechanisms involved in ovarian cancer development and how these mechanisms can be targets for prevention, detection and screening; 2. to become familiar with emerging chemo-prevention agents and early detection approaches aimed at molecular targets; 3. to learn about new high-throughput technologies and their application to ovarian cancer research; 4. to identify new areas of research based on the molecular mechanisms of the disease; and 5. to understand the implication of these modalities on the health of high-risk women and on public policy. Topics include: epidemiology; early detection, prevention and screening; new technologies; surgical- and chemo-prevention; physical, social and psychological implications of prevention, screening and genetics; and consumer/public policy perspectives. All sessions include a discussion by a leader in the field. To date, there have been no workshops specifically focused on the intersection of ovarian cancer and molecular targets; nor have there been any on high-risk women, health implication and public policy. This workshop represents a unique opportunity to bring together scientist, policy researchers and consumer advocates to advance the frontier of ovarian cancer research and public health.