Ovarian Cancer: Prevention and Its Recurrence

继我们非常成功的激素和卵巢癌预防研讨会之后，我们提出了一系列关于预防的研讨会。这一系列研讨会的目标是了解卵巢癌的遗传和生物机制，以及如何利用这些机制来设计预防和检测卵巢癌及其复发的创新策略。它将进一步讨论这些模式对妇女及其家庭生活的影响。随着分子生物学的进步和新技术(如蛋白质组学、基因组学)的出现，我们正在收集关于癌症发生的遗传学和生物学基础的非凡知识。通过直接促进我们对疾病过程的理解，这些知识和技术正在提出富有成效的初级、次级和 第三级。这一系列活动将把预防、检测和治疗研究领域的领导者聚集在一起，以交流他们的专业知识，确定研究途径并形成合作。该系列研讨会将每隔一年在匹兹堡大学癌症研究所赫伯曼会议中心举行。该系列的总主题是分子靶标和预防；每个研讨会都将有一个特定的主题：免疫系统，2005年；细胞周期，2006年；药物遗传学，2007年；激素，2008年；模型系统，2009年。目标受众是流行病学、分子生物学、遗传学、细胞生物学、内分泌学、病理学、妇科肿瘤学和高通量技术领域的基础、临床和翻译研究人员，以及公共卫生研究人员和消费者权益倡导者。具体的 研讨会的目标包括：1.进一步了解可作为预防目标的卵巢癌所涉及的分子、生物和遗传机制；2.熟悉新出现的化学预防药物和针对分子靶点的早期检测方法；3.了解新的高通量技术；4.根据疾病的分子机制确定新的研究领域；所有会议包括2-3个科学报告，然后由该领域的领导者进行公开讨论。海报会议将允许初级科学家参与，并促进更多的思想交流。到目前为止，还没有其他会议专门关注卵巢癌的交叉点， 分子靶标和预防(不包括我们2002年的研讨会)。这个系列是一个独特的机会，将科学家、政策研究人员和消费者权益倡导者聚集在一起，推动卵巢癌研究和公共卫生的前沿。

Following up on our very successful symosium on hormones and ovarian cancer prevention, we propose a series of symposia on prevention. The goal of this symposia series is to understand the genetic and biologic mechanisms involved in ovarian cancer and how these mechanisms can be exploited to devise innovative strategies for the prevention and detection of the disease and its recurrence. It will further address the impact of these modalities on the lives of women and their families. With advances in molecular biology and the emergence of new technologies (e.g., proteomics, genomics), we are gathering remarkable knowledge about the genetic and biologic basis of carcinogenesis. By directly facilitating our understanding of the disease process, this knowledge and technology is suggesting fruitful avenues of primary, secondary and tertiary. This series will bring together leaders in prevention, detection and treatment research in order to exchange their expertise, identify research avenues and form collaborations. The symposia series will be held every other year at the University of Pittsburgh Cancer Institute Herberman Conference Center. The general theme for the series is molecular targets and prevention; each symposium will have a specific theme: immune system, 2005; cell cycle 2006; pharmacogenetics, 2007; hormones 2008; and model systems 2009. The intended audience is basic, clinical and translational researchers in the areas of epidemiology, molecular biology, genetics, cell biology, endocrinology, pathology, gynecologic oncology, and high-throughput technologies, as well as public health researchers and consumer advocates. The specific goals of the workshop include: 1. to further understand the molecular, biologic and genetic mechanisms involved in ovarian cancer that can be targets for prevention; 2. to become familiar with emerging chemoprevention agents and early detection approaches aimed at molecular targets; 3. to learn about new highthroughput technologies; 4. to identify new areas of research based on the molecular mechanisms of the disease;All sessions include 2-3 scientific presentation followed by an open discussion by a leader in the field. A poster session will allow for participation by junior scientists and foster greater exchange of ideas. To date, there have been no other conferences specifically focused on the intersection of ovarian cancer, molecular targets and prevention (other than our 2002 symposium). This series represents a unique opportunity to bring together scientist, policy researchers and consumer advocates to advance the frontier of ovarian cancer research and public health.