Integrated Training in Pharmacological Sciences

描述(申请者提供)：西奈山综合培训 药理科学计划旨在提供严格的基础培训 确定治疗靶点的过程的科学基础 开发出了先导化合物。药理学作为一门学科总是在不断发展。 鉴于，药理学的核心将始终是关于“药物”的，即 药物本身正在发生变化。来自基因组和蛋白质组的新信息 科学，正在引领新的药物靶点。基因疗法，虽然仍然是主要的 试验性的，拥有巨大的治疗前景。在未来， 药物吸收、分布和消除的药代动力学原理 为小分子开发的将被常规应用于DNA输送。 认识到现代药理学的广度，我们开发了一种培训 该计划以该机构的优势为基础，包括 药物发现的新兴领域。我们的培训计划有三个主题 领域：1)分子药理学和基于结构的药物设计建立在 在大分子和蛋白质-蛋白质相互作用和 大分子结构的计算分析。2)蜂窝网络AS 药物靶点集中在细胞信号的功能特征上 路径和网络，作为确定新药物靶点的基础。 3)药理学的翻译研究利用紧密的联系 在学校和医院之间和一支有才华的生物医学干部之间 站在吸毒第一线的科学家们，从替补席一直到 我们为这个综合的多学科博士后项目寻求支持。 药理学专业。资金将用于支持学员 最长为三年的时间；通常对应于第二至第四年的培训。 在形成期间提供资金支持和药理学高级培训 预计年限会对最终的职业选择产生积极影响 由我们项目的毕业生制作。我们要求逐步增加 学生每年增加两个培训时段，最多六名学生 3-5年级；即01年级资助2名学生，02和6年级资助4名学生 03-05学年的学生。西奈山医学院及其研究 企业快速成长；支撑稳步。它目前是 在全国排名第23位。机构内的新领导层和 药理学系的研究增加了对 整个学校的药理科学系。阿瑟·H·鲁宾斯坦博士 医学院正在带头招募100多名新的 未来7年的研究人员。拉维·艾扬格博士，主席 药理学和PI的这一培训拨款，一直是催化剂 在过去的两年内招聘了4名新的教职员工。 增强的研究活动，重新配置的课程，包括 新兴领域的课程工作、轮换、研讨会和期刊俱乐部将 确保我们的学生接受广泛的现代药理学培训 并为从事药理学事业做好充分准备。

DESCRIPTION (provided by applicant): The Mount Sinai Integrated Training Program in Pharmacological Sciences aims to provide rigorous training in basic sciences underlying the processes by which therapeutic targets are identified and lead compounds developed. Pharmacology as a discipline is always evolving. Whereas, Pharmacology will always at its core be about "drugs", the nature of the drugs themselves are changing. New information from genomic and proteomic sciences, are leading to new drug targets. Gene therapy, while still primarily experimental, holds tremendous therapeutic promise. In the future, pharmacokinetic principles of drug absorption, distribution and elimination developed for small molecules will be applied routinely to DNA delivery. Recognizing the breadth of modern pharmacology, we have developed a training program that builds on the strengths of this institution and encompasses emerging areas of drug discovery. Our training program has three thematic areas: 1) Molecular Pharmacology and Structure-Based Drug Design builds on faculty expertise in macromolecular and protein-protein interactions and computational analysis of macromolecular structures. 2) Cellular Networks as Drug Targets concentrates on the functional characterization of cell signaling pathways and networks, as a basis for the identification of new drug targets. 3) Translational Research in Pharmacology takes advantage of the close ties between the school and the hospital and a cadre of talented biomedical scientists who are at the forefront of taking drugs "from the bench to the bedside." We seek support for this integrated multi-disciplinary predoctoral program in Pharmacological Sciences. Funds will be used to support trainees for a period of up to three years; generally corresponding to training years 2-4. Financial support and advanced training in Pharmacology during the formative years are expected to have a positive impact on the eventual career choices made by graduates of our program. We are requesting a gradual increase in students adding two training slots per year up to a maximum of six students in years 3-5; i.e. two students supported in year 01, 4 students in year 02 and 6 students in years 03-05. Mount Sinai School of Medicine and its research enterprise have been rapidly growing; support has steadily. It is currently ranked 23rd in the country. New leadership within the institution and the Department of Pharmacology has resulted in increased research in Pharmacological Sciences across the school. Dr. Arthur H. Rubenstein, Dean of the School of Medicine, is spearheading the recruitment of over a hundred new research faculty in the next 7 years. Dr. Ravi Iyengar, Chairman of Pharmacology and PI of this training grant, has been the catalyst for recruiting 4 new faculty members to the Department within the last two years. The enhanced research activities, a reconfigured curriculum that includes course-work in emerging areas, rotations, seminars, and journal clubs will ensure that our students will receive a broad training in modern Pharmacology and be very well prepared to pursue a career in Pharmacology.