Xenon Polarization Transfer Contrast MRI of Lung

描述(由申请人提供)：我们建议开发一种核磁共振 基于最新发明的氙气偏振的脉冲序列封装 传递对比(XTC)磁共振成像。在吸入一批超极化的 129Xe，亲脂的氙气几乎瞬间溶解在肺组织中 还有血。尽管只有一小部分气体(约2%)是 在任何时间点都会解散，但它仍在快速交换 在肺的空气空间中有更大的气池。有选择性的 ~(129)Xe固溶后的磁化强度的破坏 离开气相的一系列频率选择性射频脉冲 不受干扰的磁化使其能够编码某些生理上的 气相图像中随强度变化的实质参数 所提出的交换参数和它们的精确表征 健康受试者的可变性以及可获得的最大限度 动态范围是成功的MRI脉冲序列的关键步骤 实施。这些结果将使一部小说的发展成为可能， 非侵入性体内诊断工具，可敏化一系列 肺形态或功能的病理改变。

DESCRIPTION (provided by applicant): We are proposing the development of an MRI pulse sequence package based on the recently invented Xenon Polarization transfer Contrast (XTC) MRI. Upon inhalation of a batch of hyperpolarized 129Xe, the lipophilic xenon dissolves almost instantaneously in the lung tissue and the blood. Although only a small fraction of the gas (ca. 2 percent) is dissolved at any point in time it is nevertheless standing in fast exchange with the much larger gas pool in the air spaces of the lung. Selective destruction of the magnetization of the dissolved 129Xe with the application of a series of frequency selective radio frequency pulses that leave The gas phase magnetization undisturbed makes it possible to encode certain physiological parameters of the parenchyma as intensity variations in the gas phase images The proposed precise characterization of the exchange parameters and their variability in healthy subjects as well as the maximization of the available dynamic range are the key steps for a successful MRI pulse sequence implementation. These results will permit the development of a novel, noninvasive in-viva diagnostic tool that can be sensitized for a range of pathological changes in the lung morphology or function.