Novel Pyrogen Removal System

说明（由申请人提供）：要求无热原水（PFW）， 许多应用程序。实验室将其用作化合物制备的溶剂， 培养基和设备冲洗。医院用它来清洁 注射液静脉注射和血液透析药品生产企业 用它来配制注射药物制剂。致热原或发热诱导物， 来自细菌、霉菌、酵母、病毒的代谢副产物， 某些化学物质。 目前用于制备PFW的技术包括蒸馏，反渗透， 和超滤。总的来说，这些过程是复杂的，容易失败， 并且在许多情况下不能去除足够的热原， 规模设施。在该计划中，紧凑型膜系统（CMS） 确定了一个简单的（按下一个按钮）系统，可以轻松集成到 现有的热原去除系统。 CMS技术的基础是一种新型的氧化系统， 微生物并氧化其内毒素。在第一阶段，我们将开发 新型氧化系统，与 现有技术。 拟定商业应用： 注射用水包括肾透析用水和制药用水。

DECRIPTION (Provided by applicant): Pyrogen-free water (PFW) is required in many applications. Laboratories use it as solvent for compound preparation, culture media, and equipment rinse. Hospitals use it for cleaning to prepare solutions for injections, lV's, and hemodialysis. Pharmaceutical manufacturers use it to formulate injectable drug preparations. Pyrogens, or fever-inducers, are derived from metabolic byproducts of bacteria, molds, yeasts, viruses, and certain chemicals. Current technology used to prepare PFW include distillation, reverse osmosis, and ultrafiltration. Overall these processes are complicated, prone to failure, and in many cases do not remove sufficient pyrogens and are not ideal for small scale facilities. In this program, Compact Membrane Systems (CMS) has identified a simple (push one button) system that is easily integrated into existing systems for pyrogen removal. The basis of the CMS technology is a novel oxidizing system that both kills microorganisms and oxidizes their endotoxins. In Phase I we will develop this novel oxidizing system and demonstrate superior pyrogen removal compared to existing technologies. PROPOSED COMMERCIAL APPLICATION: Water for Injection including Kidney Dialysis water and pharmaceutical water.