Novel Detector for Small Animal SPECT Imaging

核医学技术（如SPECT）有潜力成为小型实验动物生物过程成像的强大新工具。随着人类疾病模型的不断增加，特别是在小鼠和大鼠等较小的动物中，高分辨率核医学核医学技术提供独特信息的潜力对许多研究人员来说越来越明显。临床放射性核素系统不适合小动物成像，因为它们的空间分辨率不够。这使得商用SPECT系统不适合成像小动物，因为它们的空间分辨率不够。这使得商用SPECT系统不适合在小鼠体内分辨毫米大小的结构。因此，需要专用的低成本仪器进行小动物研究，具有比目前临床SPECT扫描仪更高的空间分辨率。本研究的目的是研究一种用于小动物SPECT成像的位置敏感检测器的新概念。所提出的方法有望提供高空间分辨率，并且与正在研究的其他方法相比，该系统有望更简单，成本更低。核医学包括正电子发射断层扫描、单光子发射计算机断层扫描、放射学、无损检测、材料研究、x射线衍射、核与高能物理研究、天文学、地质勘探等。

Nuclear medicine techniques (such as SPECT) have the potential to become powerful new tools in imaging biological processes in small laboratory animals. With the every increasing number of human disease models, particularly in the smaller animals such as mice and rats, the potential of high resolution nuclear medicine nuclear medicine technologies to contribute unique information is becoming apparent to many researchers. Clinical radionuclide systems are not suitable for imaging small animals because their spatial resolution is not adequate. This makes commercial SPECT systems are not suitable for imaging small animals because their spatial resolution is not adequate. This makes commercial SPECT systems unsuitable for resolving millimeter- sized structures in mice. Hence, dedicated, low cost instruments are required for conducting small animal studies with higher spatial resolution than what is current achieved with clinical SPECT scanners. The goal of the proposed research is to investigate a novel position sensitive detector concept for small animal SPECT imaging. The proposed approach is expected to provide high spatial resolution, and the system is expected to be simpler and lower in cost as compared to other approaches being investigated. Nuclear medicine including positron emission tomography, and single photon emission computed tomography, radiology, non-destructive testing, materials research, X-ray diffraction, nuclear and high energy physics research, astronomy, and geological exploration.