Determining further differences to stable and rupture prone atherosclerotic plaques through a materials science-based approach

这个由MRC资助的博士培训伙伴关系（DTP）将尖端的分子和分析科学与数据分析中的创新计算方法结合在一起，使学生能够解决以假设为主导的生物医学研究问题。这是一个为期4年的计划，其第一年涉及一系列教学模块和两个基于实验室的研究项目，导致跨学科生物医学研究硕士学位。前两个学期包括一系列教学模块，让学生在多学科科学中获得坚实的基础。学生还参加了一系列由学术和行业专家领导的大师班，这些专家在分子，细胞和组织动力学，微生物学和感染，应用生物医学技术以及人工智能和数据科学领域。在第三和夏季学期，学生在他们选择的实验室进行两个为期11周的研究项目。项目：心脏病发作和中风的风险，这两种全球主要的死亡原因，可以通过采用新的诊断技术来降低，这些技术可以识别动脉中的高风险脂肪沉积物（斑块）。虽然一些斑块可以保持稳定多年，但其他高风险斑块往往不稳定，导致斑块形成裂缝和破裂，其碎片可以通过血流堵塞直径较小的血管，导致心脏病发作或中风。目前的技术能够识别所有斑块的一些特征，但没有一种被接受为选择性检测不稳定斑块的可靠方法。该项目将专注于测试基于材料科学的技术的有效性，以更早地识别这些斑块，可能导致心脏病发作和中风的新预防性治疗。拟议的研究受到明确的健康问题，知识差距的启发，并与MRC的职权范围密切一致，特别是预防和早期发现，开发一个完整的系统方法，并与用户密切合作，将医疗保健转向早期预防疾病。来自诊断技术的新见解在针对性预防工作以及早期诊断和行动方面发挥着越来越重要的作用。这项研究为学生提供了一个机会，使他们能够在沃里克的学者和当地NHS信托基金（UHCW）的临床医生之间建立一种合作方法，以促进健康和经济影响。学生将培养MRC优先主题领域的技能，包括定量技能（包括分析，数学，统计和数据分析）和化学，物理，工程，计算分析和临床之间的接口的跨学科技能。

This MRC-funded doctoral training partnership (DTP) brings together cutting-edge molecular and analytical sciences with innovative computational approaches in data analysis to enable students to address hypothesis-led biomedical research questions. This is a 4-year programme whose first year involves a series of taught modules and two laboratory-based research projects that lead to an MSc in Interdisciplinary Biomedical Research. The first two terms consist of a selection of taught modules that allow students to gain a solid grounding in multidisciplinary science. Students also attend a series of masterclasses led by academic and industry experts in areas of molecular, cellular and tissue dynamics, microbiology and infection, applied biomedical technologies and artificial intelligence and data science. During the third and summer terms students conduct two eleven-week research projects in labs of their choice. Project:The risk of heart attacks and strokes, both major causes of death globally, may be lowered through the adoption of new diagnostic techniques that can identify high-risk fatty deposits (plaques) in arteries. While some plaques can remain stable for years, other high-risk plaques tend to be unstable which lead to the formation of cracks and rupture of the plaque, fragments of which can travel through the blood stream to occlude vessels of smaller diameter, causing heart attacks or stroke. Current techniques are able to identify some characteristics of all plaques but none are accepted as reliable methods for selectively detecting unstable plaques. This project will focus on testing effectiveness of material-science based techniques to identify these plaques earlier, potentially leading to new preventive treatments for heart attacks and strokes. The proposed research is inspired by clear health problems, knowledge gaps and strongly aligns with the MRC remit, particularly, prevention and early detection, development a whole systems approach, and close engagement with users to shift healthcare towards pre-empting disease in earlier stages. New insights from diagnostic technologies, play an increasingly key role in targeting preventive work, and in enabling earlier diagnosis and action. The research represents an opportunity for the student to develop a collaborative approach for health and economic impact between academics at Warwick and clinicians at a local NHS Trust (UHCW). The student will develop skills in MRC priority theme areas including quantitative skills (including analytical, mathematical, statistics and data analysis) and interdisciplinary skills at the interfaces between chemical, physical, engineering, computational analysis and the clinic.