ELECTROPHYSIOLOGY

这个项目的主要目标是确定慢性阻塞性肺疾病的影响 重度饮酒对事件相关电位和脑电相干的影响 HIV病的功能性中枢神经系统发病率。慢性重度酒精使用可能 影响艾滋病毒中枢神经系统对寻求治疗和治疗依从性的影响)或 导致治疗反应降低，从而导致中枢神经系统增加 发病率。它还可以对中枢神经系统产生直接和特定的影响 不受整个艾滋病毒疾病进程进展的影响。两个都是 这些机制及其效果将在横断面上进行评估 HIV+和HIV-HIV慢性重度饮酒者和轻度/非饮酒者的研究 纵向随访两年。我们的艾滋病毒协同模型 感染和饮酒预测中枢神经系统在个体中的发病率 HIV+和慢性重度酒精使用者的人数将超过 HIV+轻饮者/不饮酒者和 长期大量饮酒的艾滋病患者。我们假设这是 大量饮酒对行为的影响会产生协同效应 关于寻求治疗、治疗坚持、营养或危险行为 (这可能导致重复接种新的病毒株)或 重度酒精使用者的生物效应(例如，对 治疗药物的代谢和生物利用度)。 我们将：(1)确定慢性重酒是否使用HIV+ 根据电生理学的测量，个体的中枢神经系统发病率更高 检测结果比不饮酒或不饮酒的HIV感染者更能确定 HIV+重度饮酒者中枢神经系统发病率 电生理测试的进展速度较大或较小 与HIV+轻度/非饮酒者的治疗反应比较，(3) 确定长期大量饮酒和艾滋病毒的影响 感染对中枢神经系统发病率电生理测定的影响 基准线及后续期间为累加或超过累加 效果，(4)在计划项目赠款的范围内，测试 关于CNS信息加工机制的两种假说 以及关于这些残疾对临床的影响 重要成果。 我们将招募和研究四组对象：120名慢性重型 饮酒HIV+个人，120名轻度/不饮酒HIV+ 个人，60名长期大量饮酒的艾滋病毒携带者，以及60名轻度/非 喝艾滋病毒的人。我们将检查其完整性和速度 涉及皮质和大脑皮质的各种信息处理操作 皮质下-皮质连接和/或皮质/皮质下区域。 信息处理能力将通过脑电进行评估 (EEG)皮质连接性和事件相关电位(ERP)测量 语义网络激活指数和大脑激活指数 定向对新刺激的反应。

The primary goal of this project is to determine the effect of chronic heavy alcohol use on event-related potential and EEG coherence measures on functional CNS morbidity of HIV disease. Chronic heavy alcohol use may affect HIV CNS effects on treatment seeking and treatment adherence) or result in a reduced treatment response which would cause increased CNS morbidity. It can also have direct and specific effects on the CNS independent of the progression of the overall HIV disease process. Both of these mechanisms and their effect will be evaluated in a cross-sectional study of HIV+ and HIV- chronic heavy drinkers and light/non-drinkers with longitudinal follow-up at two years. Our synergistic model of HIV infection and alcohol use predicts that the CNS morbidity in individuals who are HIV+ and are chronic heavy alcohol users will be greater than the sum of that in individuals who are HIV+ light/non-drinkers and that in individuals who are HIV-chronic heavy drinkers. We hypothesize that this synergy will occur as a result of behavioral effects of heavy alcohol use on treatment seeking, treatment adherence, nutrition, or risk behaviors (which could lead to repeated inoculations with new viral strains) or biological effects of heavy alcohol user (e.g., possible effects on the metabolism and bioavailability of treatment medications). We will: (1) determine whether chronic heavy alcohol using HIV+ individuals have greater CNS morbidity as measured by electrophysiological testing than do light/non-drinking HIV+ individuals, 92) determine whether HIV+ heavy drinking individuals' CNS morbidity as measured by electrophysiological testing has a greater rate of progression or a lesser treatment response compared to HIV+ light/non-drinking individuals, (3) determine whether the effects of chronic heavy alcohol use and HIV infection on electrophysiological measurements of CNS morbidity at baseline and over the follow-up period are additive or, exceeding additive effects, (4) within the context of the Program Project Grant, test hypotheses both about the mechanisms underlying CNS information processing disabilities and about the impact of these disabilities of clinically important outcomes. We will recruit and study four groups of subjects: 120 chronic heavy alcohol drinking HIV+ individuals, 120 light/non-drinking HIV+ individuals, 60 chronic heavy drinking HIV-individuals, and 60 light/non- drinking HIV-individuals. We will examine the integrity and speed of various information processing operations involving cortico-cortical and subcortical-cortical connections and/or cortical/subcortical regions. Information processing abilities will be assess by electroencephalographic (EEG) measures of cortical connectivity and event-related potential (ERP) indices of the activation of semantic networks and of the brain's orienting response to novel stimuli.