Network Synchrony Neurofeedback for Opioid Dependence

项目概要/摘要 在过去的二十年里，我们的实验室已经描述了静息状态下的适应性变化， 长期（多年）药物依赖个体的脑网络同步性 戒酒和戒毒（LTA）。这些适应性变化超过反向网络 与活性物质依赖相关的静息态同步（RSS）差异 (i.e.,增加食欲驱动网络RSS和减少抑制控制和情绪- 调节网络RSS）。我们还表明，基于EEG相干性的指数反映了这些 相同的网络在相同的个体中。我们最近实现了实时64通道 基于EEG相干性的网络同步神经反馈（NFB）训练大脑模仿 LTA发生的变化。第一阶段的SBIR工作将在一年内提供12个这样的NFB会议。 接受Subocade注射剂药物辅助治疗的阿片类药物依赖者的8周治疗期 治疗（MAT）。配对的受试者将采用交叉设计进行研究， 接受NFB的受试者随后进行8周随访，而他们的同行接受8周随访。 等待名单其次是NFB。非NFB间期允许我们估计正常的RSS变化 没有NFB，并测量NFB效应的持续性。

Project Summary/Abstract Over the last two decades, our laboratory has characterized adaptive changes in resting state brain network synchrony in substance dependent individuals with long-term (multi-year) abstinence (LTA) from alcohol and drugs. These adaptive changes more than reverse network resting-state synchrony (RSS) differences that are associated with active substance dependence (i.e., increased appetitive drive network RSS and decreased inhibitory control and emotion- regulation network RSS). We have also shown that EEG coherence based indices reflect these same networks in the same individuals. We have recently implemented real-time 64-channel EEG coherence-based network synchrony neurofeedback (NFB) to train the brain to mimic the changes that occur with LTA. This Phase I SBIR effort will provide 12 such NFB sessions over a 8 week period to opioid dependent individuals receiving Sublocade injection Medication Assisted Treatment (MAT). Matched pairs of subjects will be studied with a cross-over design, with half of subjects receiving NFB followed by a 8 week follow-up, and their counterparts being on a 8 week waiting list followed by NFB. The non-NFB intervals allows us to estimate normal RSS changes without NFB and measure the persistence of NFB effects.