Network Synchrony Neurofeedback for Opioid Dependence

阿片类药物依赖的网络同步神经反馈

• 批准号: 10382736
• 负责人: George Fein
• 金额: $ 26.93万
• 依托单位: NEUROBEHAVIORAL RESEARCH, INC.
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-30 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10382736
• 关键词: Abstinence; Alcoholism; Amplifiers; Attenuated; Behavior; Brain; Buprenorphine; COVID-19; Clinic; Clinical; Compulsive Behavior; Consumption; Crossover Design; Cues; Desire for food; Development; Drug Exposure; Drug usage; Electrodes; Electroencephalography; Emotional; Emotions; Evidence based treatment; Frequencies; Functional Magnetic Resonance Imaging; Funding; Goals; Growth; Impulsive Behavior; Impulsivity; Individual; Injectable; Injections; Intervention; Laboratories; Maintenance; Maps; Measures; National Institute on Alcohol Abuse and Alcoholism; Network-based; Opiate Addiction; Outcome; Outpatients; Patients; Pattern; Pharmaceutical Preparations; Phase; Phase II Clinical Trials; Process; Protocols documentation; Public Health; Rest; Saline; Sampling; Scalp structure; Seeds; Small Business Innovation Research Grant; Stimulus; Study Subject; Substance Addiction; Substance Use Disorder; System; Technology; Time; Training; Treatment Protocols; Waiting Lists; alcohol abstinence; alcohol use disorder; base; clinical efficacy; cognitive neuroscience; comorbidity; coronavirus disease; cost; data fusion; emotion regulation; follow-up; functional magnetic resonance imaging/electroencephalography; increased appetite; indexing; medication-assisted treatment; multimodal data; neurofeedback; opioid use; opioid use disorder; relapse risk; response; reward processing

Project Summary/Abstract Over the last two decades, our laboratory has characterized adaptive changes in resting state brain network synchrony in substance dependent individuals with long-term (multi-year) abstinence (LTA) from alcohol and drugs. These adaptive changes more than reverse network resting-state synchrony (RSS) differences that are associated with active substance dependence (i.e., increased appetitive drive network RSS and decreased inhibitory control and emotion- regulation network RSS). We have also shown that EEG coherence based indices reflect these same networks in the same individuals. We have recently implemented real-time 64-channel EEG coherence-based network synchrony neurofeedback (NFB) to train the brain to mimic the changes that occur with LTA. This Phase I SBIR effort will provide 12 such NFB sessions over a 8 week period to opioid dependent individuals receiving Sublocade injection Medication Assisted Treatment (MAT). Matched pairs of subjects will be studied with a cross-over design, with half of subjects receiving NFB followed by a 8 week follow-up, and their counterparts being on a 8 week waiting list followed by NFB. The non-NFB intervals allows us to estimate normal RSS changes without NFB and measure the persistence of NFB effects.

项目摘要/摘要 在过去的二十年里，我们的实验室描述了静息状态的适应性变化。 长期(多年)物质依赖个体的脑网络同步性 戒酒戒毒(LTA)。这些适应性变化比反向网络更多 与活性物质依赖相关的静息状态同步性(RSS)差异 (即，增加了食欲驱动网络RSS，减少了抑制控制和情绪- 监管网络RSS)。我们还表明，基于脑电一致性的指数反映了这些 在相同的个人中存在相同的网络。我们最近实现了实时频道 基于脑电相干的网络同步神经反馈(NFB)训练大脑模仿 与LTA一起发生的更改。这项第一阶段的SBIR工作将在 阿片依赖者接受亚受体阻滞剂注射药物辅助治疗的8周 治疗(垫子)。配对的受试者将用交叉设计进行研究，其中一半 接受NFB治疗的受试者随后接受8周的随访，而他们的受试者则接受8周的随访 等待名单上紧随其后的是NFB。非NFB间隔允许我们估计正常的RSS变化 在没有NFB的情况下，测量NFB效应的持久性。