Cerebellar Structure and Function Studies in Very Early Abstinence
早期禁欲中的小脑结构和功能研究
基本信息
- 批准号:9268635
- 负责人:
- 金额:$ 42.32万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2015
- 资助国家:美国
- 起止时间:2015-07-01 至 2019-04-30
- 项目状态:已结题
- 来源:
- 关键词:AbstinenceAffectAffectiveAgeAlcohol abuseAlcohol consumptionAlcoholismAlcoholsAlgorithmsAnatomyAnteriorAppearanceAtlasesAtrophicAttentionBehaviorBrainBrain regionCerebellar vermis structureCerebellumCerebrumChronicClinicalComputer softwareControlled StudyDataEquilibriumGaitGenderGoldGrantHumanImageImage AnalysisImpaired cognitionImpairmentInpatientsIntramural Research ProgramKnowledgeLabelLanguageLateralLobuleMagnetic Resonance ImagingManualsMeasurementMeasuresMedical ImagingMethodologyMethodsModelingMotionMotorMovementNational Institute on Alcohol Abuse and AlcoholismParticipantPathologyPatientsPatternPhaseProblem SolvingProtocols documentationRecoveryResolutionScanningShapesShort-Term MemorySmall Business Innovation Research GrantStructural defectStructureSurfaceTestingTimeTreatment ProtocolsUnited States National Institutes of HealthValidity and ReliabilityVisuospatialWorkalcohol effectalcohol exposurebasebrain volumeclinically significantcognitive taskcognitive testingcohortexecutive functionhigh resolution imagingimaging studyin vivomotor impairmentneuroimagingneuropathologynovelproblem drinkerprospectivepublic health relevanceskillstool
项目摘要
DESCRIPTION (provided by applicant): Cerebellar shrinkage (especially involving the anterior superior cerebellar vermis) is among the most salient and clinically significant morbid effects of chronic hazardous alcohol consumption on brain structure. Previous magnetic resonance imaging (MRI) studies of alcohol's effect on the cerebellum relied on manual delineation, because cerebellar anatomy, with foliations narrower than standard image resolution and indistinct lateral vermis boundaries, poses particular challenges for automated segmentation algorithms. Under an SBIR Phase I grant, we (NRI) developed a novel algorithm for segmentation of the cerebellar hemispheres and vermis based on Active Appearance Modeling (AAM), which uses the prior knowledge of shape, image intensities and inter-shape relationships that human experts use to infer object boundaries in medical images. By taking advantage of recent advances in prospective motion tracking and correction that allow the acquisition of higher resolution and better quality cerebellar images, we propose to extend and optimize our cerebellar segmentation software to parcellate the cerebellum into 30 substructures, then to use our software to characterize cerebellar volumes in active alcoholics and cerebellar volume recovery during very early abstinence. We also propose to investigate how cerebrocerebellar circuits contribute to cognitive and motor impairment in alcoholism. Methods: 112 alcoholics admitted to the NIAAA for inpatient treatment protocols will be studied at treatment entry and at the end of inpatient treatment with whole brain (including cerebellar) structural imaging at 0.7 mm3 resolution corrected for movement using prospective motion tracking, the Fregly assessment of gait and balance, and cognitive assessment of abilities shown to be affected by cerebellar damage. Age and gender comparable controls will be studied with the same protocols. Expert manual delineation of cerebellar vermis and lobules (30 parcels) will be obtained from a subset of alcoholics and controls for use in developing a high-resolution statistical shape model and probabilistic atlas, which will allow us to optimize our cerebellar segmentation using the AAM approach combined with non-rigid registration to a cerebellar atlas. Our algorithm will be validated on alcoholics and controls with manually labeled test-retest images, then used to quantify cerebellar substructure volume on all participants. End of treatment and treatment entry measures will be compared in the alcoholic group to assess recovery of cerebellar structure and function during very early abstinence, and alcoholic data at the beginning and end of treatment will be compared to data from controls to estimate the magnitude of the alcohol-related damage. We will also determine whether disruption of the cerebrocerebellar circuit underlies cognitive and motor impairment in alcoholism by examining the correlational patterns between brain regions that comprise nodes of the circuit, followed by using multiple regional brain volumes to predict scores on tests of cognitive and motor functions subserved by the cerebrocerebellar circuit and known to be impaired in alcoholics.
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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George Fein其他文献
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{{ truncateString('George Fein', 18)}}的其他基金
Network Synchrony Neurofeedback for Opioid Dependence
阿片类药物依赖的网络同步神经反馈
- 批准号:
10382736 - 财政年份:2021
- 资助金额:
$ 42.32万 - 项目类别:
Cerebellar Structure and Function Studies in Very Early Abstinence
早期禁欲中的小脑结构和功能研究
- 批准号:
9100604 - 财政年份:2015
- 资助金额:
$ 42.32万 - 项目类别:
Automated Delineation, Parcellation and Analysis of the Cerebellum from MR Images
根据 MR 图像自动描绘、分割和分析小脑
- 批准号:
8473749 - 财政年份:2012
- 资助金额:
$ 42.32万 - 项目类别:
Automated Delineation, Parcellation and Analysis of the Cerebellum from MR Images
根据 MR 图像自动描绘、分割和分析小脑
- 批准号:
8056940 - 财政年份:2012
- 资助金额:
$ 42.32万 - 项目类别:
Long-Term Abstinence Clinical Issues and CNS Disinhibition
长期戒酒的临床问题和中枢神经系统抑制解除
- 批准号:
7833329 - 财政年份:2009
- 资助金额:
$ 42.32万 - 项目类别:
Long-Term Abstinence Clinical Issues and CNS Disinhibition
长期戒酒的临床问题和中枢神经系统抑制解除
- 批准号:
7463348 - 财政年份:2008
- 资助金额:
$ 42.32万 - 项目类别:
Long-Term Abstinence Clinical Issues and CNS Disinhibition
长期戒酒的临床问题和中枢神经系统抑制解除
- 批准号:
8120879 - 财政年份:2008
- 资助金额:
$ 42.32万 - 项目类别:
Long-Term Abstinence Clinical Issues and CNS Disinhibition
长期戒酒的临床问题和中枢神经系统抑制解除
- 批准号:
7683910 - 财政年份:2008
- 资助金额:
$ 42.32万 - 项目类别:
Long-Term Abstinence Clinical Issues and CNS Disinhibition
长期戒酒的临床问题和中枢神经系统抑制解除
- 批准号:
7900510 - 财政年份:2008
- 资助金额:
$ 42.32万 - 项目类别:
Long-Term Abstinence Clinical Issues and CNS Disinhibition
长期戒酒的临床问题和中枢神经系统抑制解除
- 批准号:
8308535 - 财政年份:2008
- 资助金额:
$ 42.32万 - 项目类别:
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