Long-Term Abstinence Clinical Issues and CNS Disinhibition

长期戒酒的临床问题和中枢神经系统抑制解除

基本信息

批准号：
7833329
负责人：
George Fein
金额：
$ 91.09万
依托单位：
NEUROBEHAVIORAL RESEARCH, INC.
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-25 至 2012-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7833329
关键词：
4-aminospiroperidol Abstinence Acetylcysteine Affect Age Alcohol abuse Alcohol dependence Alcoholism Alcohols Amygdaloid structure Anxiety Area Arts Behavior Brain Cerebellum Characteristics Clinical Cognitive Communities Corpus Callosum Cross-Sectional Studies Data Decision Making Dependence Diagnosis Diagnostic Diffusion Disease Disinhibition Drug Addiction Drug abuse Drug usage EP300 gene Equilibrium Esthesia Event Face Family history of Funding Gait Gambling Gender Goals Hippocampus (Brain)Image Impairment Individual Inherited Iowa Laboratories Light Longitudinal Studies Magnetic Resonance Imaging Measurement Measures Mental disorders Methodology Mood Disorders Moods Neurobiology Neurologic Nicotine Parietal Lobe Pharmaceutical Preparations Population Predictive Factor Predisposition Prevalence Process Psychiatric Diagnosis Public Health Recording of previous events Recovery Recruitment Activity Relapse Reporting Rewards Role Sampling Socialization Stimulus Structure Subgroup Suggestion Symptoms System Testing Tissues Visual Visuospatial Woman Work addiction anti social base behavior test cognitive function cognitive recovery cohort deviant disability drinking drug/alcohol abstinence executive function gray matter improved information processing male meetings men non-alcoholic problem drinker psychologic response

项目摘要

DESCRIPTION (provided by applicant): In this proposed competitive revision, we are adding a longitudinal component for people in early abstinence to our funded R01 studying clinical issues and CNS disinhibition in short- and long-term abstinent alcoholics compared to non-alcoholic controls. Restudying the short term abstinent sample at 5 and 10 months after their initial assessment will directly examine the changes that occur within the first year of abstinence and/or with relapse to active drinking. The data to be gathered will leverage on the funded R01, and will be of enormous value in determining which characteristics of LTAAs represent changes with abstinence vs. which represent selection variables determining which individuals are able to achieve long-term abstinence. Although this revision is to our R01 studying abstinence, it also is directly relevant to our other R01 on Treatment Na¿ve Active Alcoholics (which was funded with a 0.7 percentile score). In that project, we are studying essentially functional alcoholics in the community. Only about 1/4 of alcoholics seek treatment, and our work has shown that they are not as 'sick' as our LTAA, and by implication, not as sick as alcoholics who try to stop, but are unsuccessful. In this competitive revision proposal, short-term abstinent alcoholics who relapse are just that group - alcoholics who try to stop, but are unsuccessful. Thus, although this application is a supplement to our long-term abstinence project, it will also serve to supplement and strengthen our treatment-na¿ve alcoholic R01. PUBLIC HEALTH RELEVANACE: This proposed competitive revision adds a longitudinal component for people in early abstinence to our funded cross-sectional R01 studying clinical issues and CNS disinhibition in short- and long-term abstinent alcoholics compared to non-alcoholic controls. The data to be gathered will leverage on the funded R01, and will be of enormous value in determining which characteristics of LTAAs represent changes with abstinence vs. which represent selection variables determining which individuals are able to achieve long-term abstinence.

描述（由适用提供）：在此拟议的竞争性修订中，我们正在为我们的资助的R01添加一个纵向组成部分，以与非酒精对照相比，在短期和长期戒酒中研究临床问题和中枢神经系统抑制。在初步评估后的第5个月和10个月内，将短期戒烟样本重新列出将直接检查在禁欲的第一年和/或主动饮酒中发生的变化。要收集的数据将利用资助的R01利用，并且在确定LTAA的哪些特征代表禁欲的变化方面具有巨大的价值，而哪个代表选择变量，确定哪些人能够实现长期戒烟。尽管此修订与我们的R01研究禁欲有关，但它也与我们的其他R01有关Active Active Bolachics（以0.7％的评分资助）直接相关。在该项目中，我们正在社区中研究基本功能性的酗酒者。只有大约1/4的酗酒者寻求治疗，我们的工作表明它们不像我们的LTAA那样“病”，并且暗示不像试图停止但没有成功的酗酒者那样生病。在这项竞争性的修订建议中，继电器的短期禁忌酗酒者只是那个群体 - 试图停止但没有成功的酗酒者。尽管这项应用是我们长期禁欲项目的补充，但它也将有助于补充和加强我们的治疗方法。公共卫生相关性：这项拟议的竞争性修订为人们早期戒酒的人们增加了纵向成分，以与非非酒精对照组相比，在短期和长期戒烟中研究临床问题和中枢神经系统抑制中枢神经系统抑制。要收集的数据将利用资助的R01利用，并且在确定LTAA的哪些特征代表禁欲的变化方面具有巨大的价值，而哪个代表选择变量，确定哪些人能够实现长期戒烟。