Long-Term Abstinence Clinical Issues and CNS Disinhibition

长期戒酒的临床问题和中枢神经系统抑制解除

• 批准号: 7833329
• 负责人: George Fein
• 金额: $ 91.09万
• 依托单位: NEUROBEHAVIORAL RESEARCH, INC.
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-25 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7833329
• 关键词: 4-aminospiroperidol; Abstinence; Acetylcysteine; Affect; Age; Alcohol abuse; Alcohol dependence; Alcoholism; Alcohols; Amygdaloid structure; Anxiety; Area; Arts; Behavior; Brain; Cerebellum; Characteristics; Clinical; Cognitive; Communities; Corpus Callosum; Cross-Sectional Studies; Data; Decision Making; Dependence; Diagnosis; Diagnostic; Diffusion; Disease; Disinhibition; Drug Addiction; Drug abuse; Drug usage; EP300 gene; Equilibrium; Esthesia; Event; Face; Family history of; Funding; Gait; Gambling; Gender; Goals; Hippocampus (Brain); Image; Impairment; Individual; Inherited; Iowa; Laboratories; Light; Longitudinal Studies; Magnetic Resonance Imaging; Measurement; Measures; Mental disorders; Methodology; Mood Disorders; Moods; Neurobiology; Neurologic; Nicotine; Parietal Lobe; Pharmaceutical Preparations; Population; Predictive Factor; Predisposition; Prevalence; Process; Psychiatric Diagnosis; Public Health; Recording of previous events; Recovery; Recruitment Activity; Relapse; Reporting; Rewards; Role; Sampling; Socialization; Stimulus; Structure; Subgroup; Suggestion; Symptoms; System; Testing; Tissues; Visual; Visuospatial; Woman; Work; addiction; anti social; base; behavior test; cognitive function; cognitive recovery; cohort; deviant; disability; drinking; drug/alcohol abstinence; executive function; gray matter; improved; information processing; male; meetings; men; non-alcoholic; problem drinker; psychologic; response

DESCRIPTION (provided by applicant): In this proposed competitive revision, we are adding a longitudinal component for people in early abstinence to our funded R01 studying clinical issues and CNS disinhibition in short- and long-term abstinent alcoholics compared to non-alcoholic controls. Restudying the short term abstinent sample at 5 and 10 months after their initial assessment will directly examine the changes that occur within the first year of abstinence and/or with relapse to active drinking. The data to be gathered will leverage on the funded R01, and will be of enormous value in determining which characteristics of LTAAs represent changes with abstinence vs. which represent selection variables determining which individuals are able to achieve long-term abstinence. Although this revision is to our R01 studying abstinence, it also is directly relevant to our other R01 on Treatment Na¿ve Active Alcoholics (which was funded with a 0.7 percentile score). In that project, we are studying essentially functional alcoholics in the community. Only about 1/4 of alcoholics seek treatment, and our work has shown that they are not as 'sick' as our LTAA, and by implication, not as sick as alcoholics who try to stop, but are unsuccessful. In this competitive revision proposal, short-term abstinent alcoholics who relapse are just that group - alcoholics who try to stop, but are unsuccessful. Thus, although this application is a supplement to our long-term abstinence project, it will also serve to supplement and strengthen our treatment-na¿ve alcoholic R01. PUBLIC HEALTH RELEVANACE: This proposed competitive revision adds a longitudinal component for people in early abstinence to our funded cross-sectional R01 studying clinical issues and CNS disinhibition in short- and long-term abstinent alcoholics compared to non-alcoholic controls. The data to be gathered will leverage on the funded R01, and will be of enormous value in determining which characteristics of LTAAs represent changes with abstinence vs. which represent selection variables determining which individuals are able to achieve long-term abstinence.

描述（由申请人提供）：在这项拟议的竞争性修订中，我们在我们资助的R 01中增加了一个针对早期戒酒人群的纵向组成部分，研究短期和长期戒酒酗酒者与非酒精对照组相比的临床问题和CNS去抑制。在初次评估后5个月和10个月重新研究短期戒酒样本，将直接检查戒酒第一年内和/或复发到主动饮酒时发生的变化。收集的数据将利用受资助的R 01，并将在确定LTAA的哪些特征代表禁欲的变化与哪些代表决定哪些个体能够实现长期禁欲的选择变量方面具有巨大价值。尽管这次修订是对我们研究戒酒的R 01的修订，但它也与我们关于未经治疗的活跃酗酒者的其他R 01直接相关（该研究的资助分数为0.7百分位数）。在这个项目中，我们主要研究社区中的功能性酗酒者。只有大约四分之一的酗酒者寻求治疗，我们的工作表明，他们并不像我们的LTAA那样“病态”，也就是说，不像那些试图戒酒但没有成功的酗酒者那样病态。在这个有竞争力的修订提案中，短期戒酒的酗酒者谁复发只是那一组-酗酒者谁试图停止，但不成功。因此，虽然这种应用是对我们长期禁欲项目的补充，但它也将有助于补充和加强我们的治疗初治酒精R 01。 公共卫生相关性：这项拟议的竞争性修订增加了一个纵向组成部分，为人们在早期禁欲，我们资助的横截面R 01研究临床问题和中枢神经系统去抑制在短期和长期禁欲酗酒者相比，非酒精对照。收集的数据将利用受资助的R 01，并将在确定LTAA的哪些特征代表禁欲的变化与哪些代表决定哪些个体能够实现长期禁欲的选择变量方面具有巨大价值。