Clinical Outcomes in Rehabilitated Burn Children

这一建议将测试一个假设，即运动计划和每日给药重组人类生长激素将促进严重烧伤后儿童恢复到完全的生理功能。将进行一项干预研究，其中临床相关结果参数将在烧伤后3个月至1年内进行量化。一半的患者将被随机分配接受0.05 mg/kg/d的重组人类生长激素或安慰剂注射。每一组将进一步随机分配，参加在Shriners Burns医院提供的为期3个月的运动调节计划，或接受标准的家庭康复。因此，四组患者将在烧伤后一年进行研究。本研究的终点将是膝关节高度和站立高度、体重、通过40k计数器和双能x线吸收仪（DEXA）测定的瘦体重、肌肉力量、骨密度、骨组织形态测量和温哥华疤痕量表测定的疤痕形成。III型、IV型和VII型胶原蛋白的鉴定和定量也将通过皮肤活检进行。

This proposal will test the hypothesis that an exercise program and the daily administration of recombinant human growth hormone will promote recovery to full physiological function in children after severe burn injury. An intervention study will be performed in which clinically relevant outcome parameters will be quantified at 3-month intervals up to one year post-burn. Half of the patients will be randomized to receive 0.05 mg/kg/d of recombinant human growth hormone or placebo injection throughout the year. Each group will be further randomized to participate in a 3-month exercise-conditioning program offered at the Shriners Burns Hospital, or receive standard home rehabilitation. Thus, 4 groups of patients will be studied up to one year post-burn. Endpoints of this study will be knee heights and standing height, body weight, lean body mass determined by 40K-counter and dual energy x-ray absorptiometry (DEXA), muscle strength, bone density, bone histomorphometry, and scar formation by the Vancouver Scar Scale. Identification and quantitation of types III, IV, and VII collagen will also be made from skin biopsies.