CORE--EXPOSURE ASSESSMENT

描述(取自应用程序) 暴露评估核心将为评估 两个生物医学项目(10和11)中的有机氯(OC)暴露和 CBPI。在项目10中，将测量血清有机氯与以下方面的关系 帕金森？S病和在项目11中作为鱼类消费的衡量标准。为 项目7，铅的身体负荷评估将包括血铅、ZPP和 骨铅，代表多个隔室，用于沉积铅和 淘汰率变化很大。暴露评估核心还将 与所有研究项目和基因分析核心合作，以整合 从地质学研究到流行病学的主题新发现 和基础科学项目。核心将提供关于以下哪些方面的建议 对环境重要的化合物应在项目10、11、3和 项目6和9中的CBPI和分子生物学：广泛的质量控制 在整个过程中实施措施，以提供可靠的暴露数据和 在项目之间以及在此期间保持一致性 正在进行研究。拟议的风险敞口措施将提供 对新环境中存在的有机污染物和铅的全面评估 约克港沉积物，与地质项目8(OCS)密切相关 和2(领先)。核心领导和技术人员备受认可 铅和铅的环境暴露评估领域的专家 有机氯。

DESCRIPTION (Taken from application) The Exposure Assessment Core will provide analytical support for assessment of organochlorine (OC) exposures in two biomedical projects (10 and 11) and the CBPI. In Project 10, serum organochlorines will be measured in relation to Parkinson?s Disease and in Project 11 as a measure of fish consumption. For Project 7, body burden assessments for lead will include blood lead, ZPP and bone lead, representing multiple compartments for deposition of lead and widely variable rates of elimination. The Exposure Assessment Core will also work with all the research projects and the Genetic Analysis Core to integrate thematically new findings from the geological studies into the epidemiologic and basic science projects. The Core will provide advice on which environmentally important compounds should be measured in Projects 10, 11, 3 and the CBPI and molecular biology in Projects 6 and 9. Extensive quality control measures are implemented throughout to provide reliable exposure data and to maintain consistency between projects and over the years during which this research is undertaken. The proposed measures of exposure will provide an overall assessment of organic contaminants and lead that are present in New York harbor sediments, which are closely tied to the geologic Projects 8 (OCs) and 2 (lead). The Core leaders and technical staff are well recognized experts in the field of environmental exposure assessment for lead and organochlorines.