EphA2 and EphA3 Maintain Tumour Initiating Cells and are Therapeutic Targets in Brain Cancer

高级别神经胶质瘤（HGG）是最常见的成人脑癌;目前的治疗方法只增加了几个月的生存时间。我们的研究表明，脑癌特异性表达的一个家庭的细胞表面蛋白质称为Eph受体。此外，我们已经表明，用Eph抗体靶向这些受体会导致脑癌肿瘤生长的显着减少。我们现在建议测试靶向这些受体的组合，以实现更大的反应，最小的副作用。

High-grade glioma (HGG) is the most common adult brain cancer; current treatments have increased survival times by months only. Our studies have shown brain cancer specific expression of a family of cell surface proteins called Eph receptors. Furthermore we have shown targeting these receptors with Eph antibodies leads to a significant reduction in brain cancer tumour growth. We now propose to test targeting these receptors in combination to achieve greater responses with minimal side effects.