Core--Developmental susceptibility

该核心的目的是促进多学科的合作 研究计划，研究在特定阶段的环境暴露如何影响 生命周期影响对疾病和发育缺陷的易感性。 核心成员拥有独特的专业知识和广泛的兴趣， 生殖和围产期流行病学，发育生物学， 畸形学因此，在第一个供资期间，重点将放在 从先入为主到童年的接触。核心调查人员拥有 必要的兴趣和专业知识，在中心的范围内， 实施多学科项目， 信息、流行病学设计和最先进的生物标志物。 发展敏感性核心的目标是：1）培养和 扩大关于易受伤害期间暴露影响的合作研究 发育阶段，包括怀孕的不良后果，出生缺陷， 发展缺陷和儿童癌症; 2）建立有效的机制 分享想法，讨论正在进行的研究，并培养新的 跨学科的企业，整合实验室，临床， 发展研究的流行病学方法; 3）促进 分子和遗传标记纳入传统的流行病学研究 生殖和发展成果;以及，4）为 多代研究知识中心 共同关注的特定暴露的生物学和致畸性。

The purpose of this Core is to stimulate a collaborative multi-disciplinary program of research on how environmental exposures at particular stages in the life cycle affect susceptibility to disease and to deficits in development. The Core members have unique expertise and wide ranging interests in reproductive and perinatal epidemiology, developmental biology, and teratology. Therefore, during the first funding period, the focus will be on exposures from preconception through childhood. Core investigators have the necessary interests and expertise to, within the context of the Center, implement multi-disciplinary projects that incorporate mechanistic information, epidemiologic designs, and state-of-the-art biomarkers. The aims of the Developmental Susceptibility Core are to: 1) foster and expand collaborative research on the effects of exposures during vulnerable stages in development, including adverse outcomes of pregnancy, birth defects, developmental deficits and childhood cancer; 2) establish effective mechanisms for sharing ideas, discussing research in progress, and fostering new interdisciplinary ventures that integrate laboratory, clinical, and epidemiologic approaches to developmental studies; 3) promote incorporation of molecular and genetic markers into traditional epidemiology studies of reproductive and developmental outcomes; and, 4) provide a resource to the Center for knowledge related to multi-generational studies, developmental biology and teratogenicity of specific exposures of common interest.