GYNECOLOGIC ONCOLOGY GROUP

描述(申请人提供)：本申请为妇科肿瘤组(GOG)CCOP研究基地。妇科肿瘤组是治疗妇科癌症的首屈一指的临床试验小组，并制定了积极的癌症预防和控制计划。妇科肿瘤学小组的组成包括妇科肿瘤学家、内科肿瘤学家、放射肿瘤学家、病理学家、护士肿瘤学家、生物统计学家、实验室科学家、行为科学家、流行病学家等学科。由妇科肿瘤学家领导的社区调查小组的附属网络加强了GOG。这一网络由小型大学和/或大型社区医院组成，应该通过增加现有和新的CCOP组织的贡献来增加招募和登记患者参加癌症预防试验的机会，从而作为预防计划的重要补充。按照典型的多地点肿瘤医学合作小组的路线组成的CCOP机构将找到机会让患者参加由GOG开发的治疗和预防试验。然而，许多未来的预防研究将需要接触到以前在CCOP机构中未见过的患者群体。随着他们适应这些新的挑战，GOG中已经存在的分支机构网络将为预防计划的成功提供支持和领导。在以前作为研究基地的经验中，GOG的CCOP机构已经达到了治疗目标。由于CCOP未能达到预防目标，GOG失去了研究基地的地位。CCOP和预防成员妇科肿瘤附属机构的结合应该会纠正之前的不足。患者应计：在以前的研究基础资助下，从1997年到1999年，每一年的治疗试验的患者应计都是令人满意的。在预防方面，CCOP机构没有达到规定的标准。虽然这一经验表明，GOG在癌症预防研究方面的要求可能不同于其他研究基地制定的要求，但它也表明，CCOP组织可以应对这一挑战。调整所需的时间比预期的要长。然而，目前的RFA中有一项规定，允许将合作临床试验组织的成员指定为预防成员。

DESCRIPTION (provided by applicant): This application is for the Gynecologic Oncology Group (GOG) CCOP Research Base. The Gynecologic Oncology Group is the premier clinical trial group in treatment of gynecologic cancers and has developed an active cancer prevention and control program. The composition of the Gynecologic Oncology Group includes gynecologic oncologists, medical oncologists, radiation oncologists, pathologists, nurse oncologists, biostatisticians, laboratory scientists, behavioral scientists, epidemiologists and other disciplines. The GOG is strengthened by an affiliate network of community-based investigative teams led by gynecologic oncologists. This network consists of small university and/or large community hospitals and should serve as a significant supplement in the prevention program by augmenting contributions from existing and new CCOP organizations in providing enhanced opportunities for recruitment and enrollment of patients into cancer prevention trials. The CCOP institutions formed along the lines of typical multi-site medical oncology cooperative groups will find opportunities to enter patients into treatment and prevention trials developed by the GOG. However, many of the future prevention studies will require access to patient groups previously not seen in CCOP institutions. As they adjust to these new challenges, the affiliate network already in place in the GOG will provide support and leadership in making the prevention program successful. In previous experiences as a Research Base, the GOG's CCOP institutions have met treatment goals. The GOG lost its Research Base status due to failure of the CCOPs to meet prevention goals. The combination of CCOP and Prevention Member Gynecologic Oncology Affiliate institutions should correct that previous deficit. Patient Accrual: Under the previous Research Base funding, patient accrual to treatment trials was satisfactory for each year of the grant - 1997 through 1999. In terms of prevention, the CCOP institutions did not meet the standards provided. While that experience showed that the requirements of the GOG in terms of cancer prevention studies may be different from those developed by other Research Bases, it also showed that there were CCOP organizations that could meet the challenge. The time requirement for adjustment was longer than anticipated. However, there is a provision in the current RFA allowing the designation of members of the cooperative clinical trial organization as Prevention Members.