Treating Postpartum Nicotine Dependence

描述（由申请人提供）：这个指导研究科学家发展奖描述了一个培训和研究计划，旨在使候选人有资格设计和进行关于预防产后吸烟复吸的研究。虽然许多妇女在怀孕期间戒烟，但大约70%的妇女会在分娩后一年内恢复吸烟。由于在产后期间吸烟对妇女和儿童的健康都有负面影响，因此预防产后吸烟复发对公共卫生有重要的好处。然而，迄今为止，人们对产后吸烟的原因或预防知之甚少。在产后期间，情绪的变化和对体重的担忧增加是常见的，这些因素也与女性的吸烟行为有关。因此，据推测，情绪和体重的关注增加妇女的脆弱性，产后吸烟复发。 为了阐明情绪和体重问题对产后吸烟的影响，候选人提出了一项研究计划，旨在：（1）评估理论上与产后吸烟复吸相关的因素;（2）制定产后特定复吸预防计划，解决与产后复吸相关的因素;（3）测试这种产后特定复吸预防计划的可行性，可接受性和初步疗效。该研究计划与培训计划相结合，旨在建立以下领域的强大知识基础：（1）尼古丁和烟草对女性的生理影响，（2）产后影响情绪和体重的因素，以及（3）先进的纵向数据分析技术。通过本研究和培训计划开发的背景和技能将为候选人未来的职业生涯提供一个有凝聚力的框架，作为女性戒烟方法临床研究领域的独立调查员。

DESCRIPTION (provided by applicant): This Mentored Research Scientist Development Award describes a training and research plan designed to qualify the candidate to design and conduct research on the prevention of smoking relapse during the postpartum period. Although many women quit smoking during pregnancy, approximately 70% will resume smoking within a year of giving birth. Because smoking during the postpartum period has negative effects on the health of both women and children, preventing postpartum relapses to smoking can have important public health benefits. To date, however, little is known about the causes or prevention of postpartum smoking. Changes in mood and increases in concerns about weight are common during the postpartum period, and these factors also have been related to women's smoking behavior. Thus, it is hypothesized that mood and weight concerns increase women's vulnerability to postpartum smoking relapse. To elucidate the effects of mood and weight concerns on postpartum smoking, the candidate proposes a research plan designed to: (1) assess factors theoretically related to postpartum smoking relapse; (2) develop a postpartum-specific relapse prevention program addressing factors found to relate to postpartum relapse; and (3) test the feasibility, acceptability and initial efficacy of this postpartum-specific relapse prevention program. This research plan is combined with a training plan designed to establish a strong knowledge base in the following areas: (1) the physiologic effects of nicotine and tobacco on women, (2) factors in the postpartum period that affect mood and weight, and (3) advanced longitudinal data analytic techniques. The background and skills developed during through this research and training plan will provide a cohesive framework for the candidate's future career as an independent investigator in the area of clinical research on approaches to women's smoking cessation.