IMPROVEMENT TO A COBRE FOR CARDIOVASCULAR RESEARCH

描述(由申请人提供)： 这项申请的总体目标是提供急需的资金，用于购买设备以及实验室改建和翻新，以补充最近资助的科布尔奖，用于在休斯顿大学建立心血管研究中心。新资助的科布雷中心将三名全国公认的知名研究人员聚集在一起，开展了一项新颖的指导计划，以帮助五名有前途的年轻研究人员开发一项高度互动的多学科研究计划，重点关注血管壁的生物学和病因学。资助的科布尔奖得到了大学卫生学院所有参与机构的热烈支持，这种支持包括分配空间和资金，用于实验室空间的部分翻新，新的显微镜和组织学核心实验室，以及通用玻璃器皿和高压灭菌器设施。这项补充申请正在寻求额外的资金，以完成这些翻修，并为所有Cobre参与者购买通用设备，以及为新的显微镜和组织学核心实验室购买额外设备。这些补充资金将有助于科布雷中心的快速发展，并加强该中心的短期目标，为参与调查的人员成功获得新的R0I和P0I资金。在新任华盛顿大学校长和华盛顿大学医学院(约翰·A·伯恩斯医学院，夏威夷唯一的医学院)院长的新领导下，用于新科布雷中心基础设施发展的额外资金也将有助于实现大学的长期目标，即通过补充夏威夷州最近承诺的1.5亿美元，为国家卫生研究院(NIH)资助的健康科学相关研究创建一个新的研究密集型园区，从而重振生命科学研究。这一倡议已被国家确定为一项主要优先事项，通过鼓励生物技术的发展来协助迅速实现经济多样化。

DESCRIPTION (provided by applicant): The overall goal of this application is to provide urgently needed funds for equipment purchases and laboratory alterations and renovations to supplement a recently funded COBRE award for the development of a Cardiovascular Research Center at the UH. The newly funded COBRE Center has brought three nationally recognized established investigators together in a novel mentoring initiative to assist five promising young investigators in the development of a highly interactive, multidisciplinary research program focused on the biology and pathogenetics of the blood vessel wall. The funded COBRE award has been enthusiastically supported by all the participating institutions within the UH and this support has included allocations of space and funding for partial renovations of laboratory space, for a new microscopy and histology core laboratory and a common-use glassware and autoclave facility. This supplemental application is seeking additional funding to complete these renovations and purchase equipment for both common-use for all the COBRE participants and additional equipment for the new microscopy and histology core laboratory. These supplemental funds will assist in the rapid development of this COBRE Center and enhance the short-term goal of this Center in successfully securing new R0I and P0I funding for the participating investigators. Under the new and dynamic leadership of a new President of the UH and a new Dean for the UH Medical School (The John A Burns School of Medicine; the only Medical School in Hawaii), additional funds for infrastructure development for the new COBRE Center will also assist in realizing the long term goals of the University to revitalize life sciences research through complementation of a very recent commitment of $150 million by the State of Hawaii to create a new research-intensive campus for the National Institutes of Health (NIH)-funded health sciences-related research. This initiative has been established as a major priority by the State to assist in rapid economic diversification by encouraging the growth of biotechnology