Flow Visualization in the Canine Larynx During Phonation

描述（由申请人提供）：本补助金的主要目的是 训练候选人能够独立地推导出计算和 喉疾病的理论模型，通过实验验证这些模型 在动物中，并使用理论和动物模型的结果来设计 新的医疗和外科治疗喉部疾病。课程在 流体力学、计算流体动力学、振动和声学将 为候选人提供必要的知识，以推导新的理论模型， 喉部疾病此外，候选人将开发自己的计算 发音时犬喉内气流的模型。课程将是 辅以候选人提供的演讲科学教程？的导师，博士。 罗恩谢勒。在动物实验中验证理论的经验将是 这是在这项研究的一部分。为了他的研究， 将使用他已经开发的流动可视化方法来确定 发声时喉部气流的模式。空气流动的模式 喉部很重要，因为气流产生驱动声带的力量 （绳索）振动，某些气流模式也可能产生声音， 除了声带振动之外的其他机制。当前计算和 理论模型对流动模式做出了假设， 得到了实验验证。研究者将使用血流可视化， 粒子图像测速法判断流动是否分离 发生在声门上，是否在声门上发生涡流，以及是否 声门正上方的气流是层流。然后，候选人将比较他的 实验结果与当前的理论和计算模型，并与 他的计算模型。在认识临床应用方面的培训 这项工作将通过咨询两位著名的喉科医生来促进。 杰拉尔德·伯克和兰德尔·帕尼洛医生

DESCRIPTION (provided by applicant): The primary purpose of this grant is to train the candidate to be able to independently derive computational and theoretical models of laryngeal diseases, to verify these models by experiments in animals, and to use the results of theoretical and animal models to design new medical and surgical therapies for diseases of the larynx. Coursework in fluid mechanics, computational flow dynamics, vibrations, and acoustics will give the candidate the necessary knowledge to derive new theoretical models for laryngeal diseases. In addition the candidate will develop his own computational model of airflow in the canine larynx during phonation. The coursework will be supplemented by tutorials in speech science given by the candidate?s mentor, Dr. Ron Scherer. Experience in verifying theory in animal experiments will be obtained in the research part of this proposal. For his research, the candidate will use the flow visualization method he has already developed to determine the patterns of airflow in the larynx during phonation. The pattern of airflow in the larynx is important because flow produces forces that drive vocal fold (cord) vibrations, and certain airflow patterns may also produce sound by mechanisms other than vocal fold vibration. Current computational and theoretical models make assumptions about the flow patterns that have not yet been experimentally verified. The investigator will use flow visualization and the particle image velocimetry method to determine whether flow separation occurs in the glottis, whether vortices occur above the glottis, and whether the flow directly above the glottis is laminar. The candidate will then compare his experimental findings with current theoretical and computational models and with his computational model. Training in recognizing clinical applications of the work will be fostered by consultations with two prominent laryngologists, Dr. Gerald Berke and Dr. Randal Paniello.