Molecular Change and Thyroid Cancer Risk After Chernobyl

描述（由申请方提供）：本研究将调查1986年4月26日暴露于切尔诺贝利核电站事故辐射时年龄在50岁以下的俄罗斯联邦布良斯克州居民甲状腺癌的发生率和分子特征。该研究有三个主要目的：1）根据遗传变化的特定分子标记来描述甲状腺癌病例的特征，并调查这些标记的存在是否与切尔诺贝利事故中甲状腺受到的个体甲状腺辐射剂量有关; 2）调查年龄是否在-甲状腺癌的照射依赖性辐射剂量反应在所研究的分子标志物阳性与阴性的癌症之间存在差异;和3）研究这些相同分子标记物的存在是否与临床结果相关。2001年4月1日至2006年3月31日期间诊断的甲状腺癌病例将被确定，并由甲状腺病理学家专家小组确认诊断。对照组，数量与甲状腺癌病例相同，将在布良斯克州的居民中选择，没有甲状腺癌，按性别，年龄，定居类型和爪子分别与病例相匹配。对于所有病例和对照，将收集以下信息：1）人口统计学和健康史; 2）居住和饮食史的详细信息; 3）适当的身体样本，以帮助剂量重建;和4）血液样本。将估计每例病例和对照组的甲状腺个体辐射剂量。将获得每例病例的石蜡包埋组织或新鲜冷冻组织，以评估酪氨酸激酶生长因子和酪氨酸激酶受体表达，从而估计每种标志物的存在与个体甲状腺辐射剂量之间的相关性。将从病历中收集临床病史和结局数据，以研究不良临床结局（例如复发）与个体甲状腺辐射剂量、患者特征和遗传变化的分子标志物之间的相关性。

DESCRIPTION (provided by applicant): This study will investigate the occurrence and molecular characteristics of thyroid cancer in residents of the Bryansk Oblast of the Russian Federation who were up to 50 years of age at the time of exposure to radiation from the Chernobyl Power Station accident on April 26, 1986. The study has three primary purposes: 1) to characterize cases of thyroid cancer according to specific molecular markers of genetic change, and to investigate whether the presence of such markers is associated with individual thyroid radiation dose to the thyroid from the Chernobyl accident; 2) to investigate whether age-at-exposure dependent radiation dose response for thyroid cancer differs between cancers that are positive versus negative for the molecular markers investigated; and 3) to investigate whether the presence of these same molecular markers is associated with clinical outcome. Thyroid cancer cases diagnosed between April 1, 2001 and March 31, 2006 will be identified and the diagnosis confirmed by a panel of expert thyroid pathologists. Controls, equal in number to the cases of thyroid cancer, will be selected among residents in the Bryansk Oblast, without thyroid cancer, individually matched to cases by sex, age, type of settlement and talon. For all cases and controls, the following information will be collected: 1) demographic and health history; 2) details of residential and dietary history; 3) appropriate physical samples to aid dose reconstruction; and 4) a blood sample. Individual radiation dose to the thyroid will be estimated for each case and control. Paraffin embedded tissue or fresh frozen tissue will be obtained for each case to assess tyrosine kinase growth factor and tyrosine kinase receptor expression for purposes of estimating the association between the presence of each of the markers and individual thyroid radiation dose. Clinical history and outcome data will be collected from medical records for investigation of the association between adverse clinical outcome (e.g. recurrence) and individual thyroid radiation dose, patient characteristics, and molecular markers of genetic change.