Normal Human and Schizophrenic Brain

描述：(申请人提供)有人建议精神分裂症是 大脑偏侧化的结果与大脑的 人类语言的进化。已发现正常和正常之间的差异 精神分裂症患者大脑颞叶的大小和偏侧化。多数 然而，工作一直集中在总体结构上，而忽略了 可能存在解剖学差异的相关 细胞构造区。此外，审查这一问题将有利可图。 与已知功能意义相关的解剖成分。这样的一个 结构是微柱，是人体最基本的解剖和生理单位 大脑皮层。微柱的形态已经被证明是不同的 较小的建筑区域，反映输入、输出和本地的变化 组织。出于这个原因，它被选为理想的解剖标记 对不对称差异的研究。在我们的初步研究中，我们 观察了11例正常人和5例正常人微柱的五种形态特征 精神分裂症患者的大脑。结果表明：1)正常儿童与正常儿童之间存在差异 精神分裂症患者的大脑并不是在水平间隔中被发现的 单元柱的内化结构，以及2)单元柱的不对称性 细胞柱涉及一个以上的解剖变量。这个项目将 检查小柱的偏侧化模式可能存在的差异 选定的皮质区域，包括韦尼克语言区域的一部分，在40 来自Runwell III收藏的52个正常大脑和52个精神分裂症大脑。 Lamina III中Nissl染色的细胞柱的放大图像(1 100x)将是 通过强大的计算机映像硬件和软件启用进行分析 研究人员需要精确量化细胞柱形态的细节。如果 这项研究的初步发现得到证实，他们将证明 据报道，精神分裂症患者的颞叶差异不仅涉及 大小也是重组的一个基本单位的功能。另一种可能 结果是，颞叶中的微柱数量可能不同 在结构重组中没有伴随而来的变化。

DESCRIPTION: (provided by applicant) It has been proposed that schizophrenia is a consequence of the lateralization of the brain in conjunction with the evolution of human language. Differences have been found between normal and schizophrenic brains in the size and lateralization of temporal lobes. Most work, however, has concentrated on gross structures while ignoring the potential for anatomical differences that may be found in relevant cytoarchitectonic areas. Furthermore, it would be profitable to examine anatomical components that correlate with known functional significance. Such a structure is the minicolumn, a fundamental anatomical and physiological unit of the cortex. The morphology of the minicoiumn has been shown to differ between small architectonic regions, reflecting variation in input, output, and local organization. For this reason, it was chosen as the ideal anatomical marker for the investigation of asymmetrical differences. In our preliminary studies, we examined five morphological features of minicolumns in 11 normal and 5 schizophrenic brains. The results revealed that: 1) differences between normal and schizophrenic brains are found not in the horizontal spacing that separate cell columns internalized structure of the cell columns, and 2) asymmetry of cell columns involves more than one anatomical variable. This project will examine possible differences in lateralization patterns of minicolumns in selected areas of cortex, including a part of Wernicke's language area, in 40 normal and 52 schizophrenic brains derived from the Runwell III collection. Magnified images (1 100x) of Nissl-stained cell columns in Lamina III will be analyzed by powerful computer imaging hardware and software enabling researchers to precisely quantify details of cell column morphology. If the preliminary findings of this study are confirmed, they will demonstrate that the reported differences of the temporal lobe in schizophrenia involve not only size but also a reorganization of a basic unit of function. Another possible outcome is that the number of minicolumns in the temporal lobe may differ without a concomitant change in the structural reorganization.