Adherence to Antiretrovirals in People Living with HIV

描述(由申请人提供)：艾滋病毒或艾滋病患者(PLWHA)经常被开出抗逆转录病毒治疗方案，以降低机会性感染的风险。这些多用药方案非常复杂和繁重，几乎需要完美的坚持。因此，抗逆转录病毒依从性差是一个令人烦恼的问题。我们提出了一个引人入胜的、识字和动机量身定制的互动网站干预措施，以促进PLWHA坚持接受高效抗逆转录病毒疗法(HAART)。该网站将以三个复杂程度编写，包括对困难单词的弹出式定义，并提供提供反馈的手段。页面的动态组装将允许定制和个性化。在第一阶段期间，通过与PLWHA和医疗保健提供者举行的焦点小组会议，我们将评估与网站内容相关的需求、优先事项和偏好，并就操作功能、个性化页面和基于网络的沟通获得想法。这些信息将被用来开发网站的试点版本，使用激励定制算法，使内容与用户愿意坚持的内容相匹配，最后，我们将对新干预措施的可行性进行初步评估。在第二阶段，我们将扩展网站的功能、内容和定制，以增强用户动机、网站有效性和重复、长期使用。然后，我们将确定反复访问网站对HAART相关知识、态度和遵守维度的潜在影响，并与非动机定制和非互动版本的影响进行比较。

DESCRIPTION (provided by applicant): People living with HIV or AIDS (PLWHA) are often prescribed an antiretroviral regimen to decrease risk for opportunistic infection. These multi-medication regimens are highly complex and burdensome and require almost perfect adherence. Consequently, poor antiretroviral adherence is a vexing problem. We propose an engaging, literacy- and motivationally tailored interactive website intervention to promote adherence to Highly Active Anti Retroviral Therapy (HAART) among PLWHA. The website will be written at three-levels of complexity, include pop-up definitions for difficult words, and provide means to deliver feedback. Dynamic assembly of pages will permit customization and personalization. Through focus group meetings with both PLWHA and health care providers during Phase I, we will assess needs, priorities, and preferences related to website content, and gain ideas for operational features, personalized pages, and web-based communication. This information will be used to develop a pilot version of the website with a motivational-tailoring algorithm that matches content to users' readiness to adhere, Finally, we will conduct a preliminary evaluation of the new intervention's feasibility. During Phase II we will expand website features, content, and tailoring to enhance user motivation, website effectiveness, and repetitive, long-term use. We will then determine the potential effects of repeated visits to the site upon HAART-related knowledge, attitudes, and adherence dimensions, as compared to the effects of non-motivationally tailored and non-interactive versions.