Development of Molecular Imprinted Polymer (MIP) nanoparticles for targeted fluorine-based Positron Emission Tomography (PET) imaging and Boron Neutro

计划探索MIP纳米颗粒针对已知癌症生物标志物的使用，并能够将18F作为PET显像剂输送到各种癌症目标。通过利用含有高10B含量的单体构建mip，研究人员计划进一步利用这些纳米颗粒来探索BNCT。这两个概念的结合有望为各种癌症提供一个强大的治疗平台。因此，该项目将有机合成技能（单体合成、MIP制备和表征、生物标志物合成）与放射化学技能（PET化学、BNCT化学）相结合。

It is planned to explore the use of MIP nanoparticles directed at known cancer biomarkers and also capable of delivering 18F to various cancer targets, as PET imaging agents. By constructing the MIPs from monomers having a high 10B content, it is further planned to explore BNCT using these nanoparticles. Combination of both concepts is hoped to lead to a powerful theranostic platform for various cancers. The project will therefore combine organic synthesis skills (monomer synthesis, MIP preparation and characterisation, biomarker synthesis) with radiochemistry skills (PET chemistry, BNCT chemistry).