Atomic Layer Deposition Enabled Perfluorinated Ligand Imprinted Molecular Layer Sensor for Total PFAS Detection

用于总 PFAS 检测的原子层沉积全氟配体印迹分子层传感器

基本信息

  • 批准号:
    2207739
  • 负责人:
  • 金额:
    $ 45万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Standard Grant
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-08-15 至 2025-07-31
  • 项目状态:
    未结题

项目摘要

As emerging contaminants, per- and polyfluoroalkyl substances make up a large group of persistent anthropogenic chemicals that are persistent and not easily degradable in the environment and in the human body. Due to their impact on human health, the exposure health advisory of perfluorooctanoic acid and perfluorooctane sulfonate in drinking water is recommended by the US Environmental Protection Agency to be no more than 70 parts per trillion. Measurements at such low concentration require ultrasensitivity. This project will illustrate how nanotechnology and sensing technology can be meshed together for ultrasensitive detection of those substances. The work will revolutionize the atomic layer deposition-enabled molecular sensing platform if successful. The outcome will not only have an enormous impact on environmental monitoring and public health, but also provide a demonstration from basic science to applications. This project will also involve the students at all levels and integrate advanced device fabrication and sensing knowledge into their education and research training. The research results will be disseminated to general public and industry companies. This multidisciplinary project aims at developing a novel, simple, portable, low-cost sensor for rapid and ultra-sensitive detection of per- and polyfluoroalkyl substances based on unique atomic layer deposition-enabled molecularly imprinting technology and ultrasensitive electrochemical signal detection in a portable platform. Several novel features crossing nano-, material- and sensing technologies will be seamlessly integrated into the sensing platform. After validation of the sensing device using spiked water samples in the controlled laboratory environment, the devices will be applied for in-field tests of river water samples. In addition, this new methodology is naturally not limited to any particular small molecules. Therefore, it can be generalized as a universal platform for monitoring a wide spectrum of small molecules of interest after molecularly imprinting.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
作为新出现的污染物,全氟烷基和多氟烷基物质构成了一大类持久性人为化学品,这些化学品具有持久性,在环境和人体内不易降解。由于其对人类健康的影响,美国环境保护署建议饮用水中全氟辛酸和全氟辛烷磺酸的接触健康咨询不超过万亿分之70。在如此低的浓度下进行测量需要超灵敏度。该项目将说明纳米技术和传感技术如何结合在一起,以实现对这些物质的超灵敏检测。如果成功,这项工作将彻底改变原子层沉积分子传感平台。其成果不仅将对环境监测和公共卫生产生巨大影响,而且将提供从基础科学到应用的示范。该项目还将涉及各级学生,并将先进的器件制造和传感知识融入他们的教育和研究培训中。研究结果将向公众和行业公司传播。该多学科项目旨在开发一种新型,简单,便携式,低成本的传感器,用于快速和超灵敏地检测全氟烷基和多氟烷基物质,该传感器基于独特的原子层沉积分子印迹技术和便携式平台中的超灵敏电化学信号检测。几个跨越纳米,材料和传感技术的新功能将无缝集成到传感平台中。在受控实验室环境中使用加标水样验证传感装置后,该装置将用于河流水样的现场测试。此外,这种新方法自然不限于任何特定的小分子。该奖项反映了NSF的法定使命,通过使用基金会的知识价值和更广泛的影响审查标准进行评估,被认为值得支持。

项目成果

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Yu Lei其他文献

Stateless techniques for generating global and local test oracles for message-passing concurrent programs
用于为消息传递并发程序生成全局和本地测试预言机的无状态技术
  • DOI:
    10.1016/j.jss.2017.11.026
  • 发表时间:
    2018
  • 期刊:
  • 影响因子:
    0
  • 作者:
    R. Carver;Yu Lei
  • 通讯作者:
    Yu Lei
Antibiotic resistance genes in landfill leachates from seven municipal solid waste landfills: Seasonal variations, hosts, and risk assessment
七个城市固体废物填埋场的垃圾渗滤液中的抗生素抗性基因:季节变化、宿主和风险评估
  • DOI:
    10.1016/j.scitotenv.2022.158677
  • 发表时间:
    2022
  • 期刊:
  • 影响因子:
    9.8
  • 作者:
    Yangqing Wang;Rui Zhang;Yu Lei;Liyan Song
  • 通讯作者:
    Liyan Song
Microenvironment-Adaptive Nanozyme for Accelerating Drug-Resistant BacteriaInfected Wound Healing
用于加速耐药细菌感染伤口愈合的微环境适应性纳米酶
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    10
  • 作者:
    Yu Lei;Sun Yiping;Niu Yusheng;Zhang Pengfei;Hu Jun;Chen Zhong;Zhang Gong;Xu Yuanhong
  • 通讯作者:
    Xu Yuanhong
Enhance Combinatorial Testing with Metamorphic Relations
通过变形关系增强组合测试
  • DOI:
    10.1109/tse.2021.3131548
  • 发表时间:
    2022
  • 期刊:
  • 影响因子:
    7.4
  • 作者:
    Xintao Niu;Yanjie Sun;Huayao Wu;Gang Li;Changhai Nie;Yu Lei;Xiaoyin Wang
  • 通讯作者:
    Xiaoyin Wang
Testing TLS using planning-based combinatorial methods and execution framework
使用基于规划的组合方法和执行框架测试 TLS
  • DOI:
  • 发表时间:
    2018
  • 期刊:
  • 影响因子:
    1.9
  • 作者:
    D. Simos;Josip Bozic;Bernhard Garn;Manuel Leithner;Feng Duan;Kristoffer Kleine;Yu Lei;F. Wotawa
  • 通讯作者:
    F. Wotawa

Yu Lei的其他文献

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{{ truncateString('Yu Lei', 18)}}的其他基金

Collaborative Research: Advanced Biomanufacturing of Functional Bionanoparticles for Biomedical Engineering Applications
合作研究:用于生物医学工程应用的功能性生物纳米颗粒的先进生物制造
  • 批准号:
    1604826
  • 财政年份:
    2016
  • 资助金额:
    $ 45万
  • 项目类别:
    Standard Grant
UNS: Signal-Amplification for Instrument-Free, Multiplexed Immunoassay - a Generalized Platform for Biosening
UNS:无仪器、多重免疫测定的信号放大 - 生物传感的通用平台
  • 批准号:
    1510468
  • 财政年份:
    2015
  • 资助金额:
    $ 45万
  • 项目类别:
    Standard Grant
UNS:Collaborative Research: Atomistic Design of High-Performance Epoxidation Catalysts with Atomic Layer Deposition and Kinetic Monte Carlo Simulations
UNS:合作研究:利用原子层沉积和动力学蒙特卡罗模拟进行高性能环氧化催化剂的原子设计
  • 批准号:
    1511820
  • 财政年份:
    2015
  • 资助金额:
    $ 45万
  • 项目类别:
    Standard Grant
Collaborative Research: Injectable, Biocompatible, Programmed-Bioresorbable Nanosensor Array for Continuous Glucose Monitoring
合作研究:用于连续血糖监测的可注射、生物相容性、程序化生物可吸收纳米传感器阵列
  • 批准号:
    1509216
  • 财政年份:
    2015
  • 资助金额:
    $ 45万
  • 项目类别:
    Standard Grant
AIR Option 1: Technology Translation - Portable, Naked Eye-based, Ultrasensitive Explosive Vapors Detector
AIR 选项 1:技术翻译 - 便携式、基于肉眼的、超灵敏爆炸性蒸气探测器
  • 批准号:
    1311865
  • 财政年份:
    2013
  • 资助金额:
    $ 45万
  • 项目类别:
    Standard Grant
I-Corps: Naked eyes-based standoff detection of explosives using novel signal-amplifying nanocomposite and hand-held UV light
I-Corps:使用新型信号放大纳米复合材料和手持式紫外线进行裸眼远距离爆炸物检测
  • 批准号:
    1157650
  • 财政年份:
    2011
  • 资助金额:
    $ 45万
  • 项目类别:
    Standard Grant
IDR/Collaborative Research: Magnetic Beads Linked Immunoassay Meets Micro Coulter Counter: Novel Multiplexed Biosensor System for Food Safety
IDR/合作研究:磁珠联动免疫分析与微库尔特计数器的结合:用于食品安全的新型多重生物传感器系统
  • 批准号:
    1014794
  • 财政年份:
    2010
  • 资助金额:
    $ 45万
  • 项目类别:
    Standard Grant
Rapid, Sensitive and Sequential Detection of E. coli and Total Coliforms Using Engineered Conducting Membranes for Water Quality Control
使用工程导电膜快速、灵敏、连续地检测大肠杆菌和总大肠菌群以进行水质控制
  • 批准号:
    0828627
  • 财政年份:
    2008
  • 资助金额:
    $ 45万
  • 项目类别:
    Standard Grant
EXP-LA: Real-time, Compact, and Ultra-sensitive Sensor Arrays for Explosives Vapor Detection
EXP-LA:用于爆炸物蒸气检测的实时、紧凑和超灵敏传感器阵列
  • 批准号:
    0730826
  • 财政年份:
    2007
  • 资助金额:
    $ 45万
  • 项目类别:
    Standard Grant

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合作研究:用于超高效功能器件组件的区域选择性原子层沉积的可扩展纳米制造平台
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