Effects of manipulating germ cell niche in immature human testis: potential mechanism for protection from chemotherapy-induced damage

化疗药物的先进发展已将儿童癌症患者的存活率提高到80%(Mariotto等人。2009年)。然而，经过治疗后，一些男性幸存者会随后变成少精子症或无精子症，这意味着这些患者未来生孩子的机会非常低(Brook等人。2001)。这些患者未来的生育能力是非常令人担忧的，尽管成人精子冷冻保存已经得到很好的证实，但青春期前男孩或那些还不能产生精子的人需要选择保存生育能力的选择(Anderson等人综述)。2015年)。

Advanced development of chemotherapeutic drugs has increased the survival rates of childhood cancer patients to 80% (Mariotto et al. 2009). However, following treatment some male survivors willsubsequently become oligospermic or azoospermic, meaning that chances for these patients to father a child in the future are very reduced (Brook et al. 2001). Future fertility for these patients is of great concern and, although sperm cryopreservation for adults is well established, pre-pubertal boys or those who are not yet able to produce sperm are in need of options for fertility preservation (reviewed in Anderson et al. 2015).