Integrating EEG to stratify severity progression and neurodegenerative risk in REM sleep behaviour disorder RBD

RBD表现为快速眼动睡眠期间骨骼肌张力失调失败，最终导致不受控制的与梦相关的运动活动，通常具有攻击性和身体性质。这些运动症状明显与RBD患者脑干回路的退化有关。然而，超过80%的50岁以上的RBD男性随后发展为更广泛的神经退行性疾病，最明显的是帕金森病（PD）。反过来，PD患者合并RBD更容易出现情感和认知功能障碍。因此，RBD构成了一个独特的前驱PD的强大模型，很好地阐明了风险，进展和非运动性症状的机制。

RBD manifests through failure of skeletal muscle atonia during REM sleep, culminating in unchecked dream-related motor activity, typically of an aggressive and physical nature. These motor symptoms clearly implicate degeneration of brainstem circuits in RBD. However, more than 80% of males over 50 presenting with RBD subsequently develop broader neurodegenerative disorders, most notably Parkinson's disease (PD). In turn, PD patients with concomitant RBD are more prone to affective and cognitive dysfunction. RBD therefore constitutes a uniquely powerful model of prodromal PD, well-placed to illuminate mechanisms of risk, progression and non-motoric symptoms.