Evolution of Duplicate Genes at the Genomic Level

描述（由申请人提供）：我们的目标是了解过程， 真核生物基因组中重复基因的进化机制。几 真核生物的基因组已经完成，还有几个很快就会完成。 完成大量的基因组序列数据对于 研究重复基因进化的各个方面。这是第一 重复基因的进化可以在基因组水平上进行研究。到 抓住这一前所未有的机遇，我们建议开展以下工作： 研究项目： 1.开发检测基因组中重复基因的方法， 将蛋白质分类为家族。 2.开发检测基因组中区块重复的方法。计算机 将开发（1）和（2）中方法的软件包。 3.评估各种真核生物基因组中基因复制的程度。为 每个完整的基因组，我们问：有多少重复基因（基因家族）存在于 基因组数据块重复发生的频率如何？与之相比， 我们会问，“哪些基因在任何一个基因组中都没有复制过？” 研究的基因组，哪些重复基因是不同基因组所共有的， 仅限于某些特定的进化谱系为什么他们如此 分布式？" 4.研究基因组中基因复制的速率。 5.为了研究重复基因的进化机制或如何复制 基因在复制事件之后进化。我们将研究各种模型 保留和进化重复基因的关键

DESCRIPTION (provided by applicant): Our goal is to understand the process and mechanisms of the evolution of duplicate genes in eukaryotic genomes. Several eukaryotic genomes have been completed and several more are soon to be completed. The huge amounts of genomic sequence data are very useful for studying various aspects of the evolution of duplicate genes. This is the first time that evolution of duplicate genes can be studied at the genomic level. To seize this unprecedented opportunity, we propose to pursue the following studies: 1. To develop methods for detecting duplicate genes in a genome and for classifying proteins into families. 2. To develop methods for detecting block duplications in a genome. A computer software package for the methods in (1) and (2) will be developed. 3. To assess the extents of gene duplication in various eukaryotic genomes. For each complete genome we ask: How many duplicate genes (gene families) exist in the genome? How often block duplication occurs? Then in comparison among genomes, we shall ask, "which genes have not been duplicated in any of the genomes studied, which duplicate genes are common to diverse genomes and which are restricted to only certain evolutionary lineages? And why are they so distributed?" 4. To study the rate of gene duplication in a genome. 5. To study the mechanisms of evolution of duplicate genes or how duplicate genes evolve following the duplication event. We shall examine various models for the retention and evolution of duplicate genes.