Enabling Technologies for Combinatorial Chemistry

这项拨款申请描述了一项旨在为有机合成和构建分子多样性开发新的合成技术的研究计划。具体地说，拟议的研究旨在探索DMP和IBX试剂的合成潜力，并开发基于邻位取代苯甲醛的光诱导化学和α-磺化羰基化合物在溶液和固相中的反应性的合成技术。并展望了这些新技术在全合成和组合化学中的应用。设计和合成的化合物将与各种用于铅鉴定的生物测试进行筛选，作为促进肿瘤学和其他疾病领域的化学生物学研究和药物发现计划的手段。

This grant application describes a research program directed at the development of new synthetic technologies for organic synthesis and molecular diversity construction. Specifically, the proposed research aims to explore the synthetic potential of the DMP and IBX reagents and to develop synthetic technologies based on the photo-induced chemistry of o- substituted benzaldehydes and the reactivity of alpha-sulfonated carbonyl compounds, both in solution and on solid phase. Applications of the developed technologies to total synthesis and combinatorial chemistry are also proposed. The designed and synthesized compounds will be screened against a variety of biological assays for lead identification as a means to facilitate chemical biology studies and drug discovery programs in oncology and other disease areas.