Human Papillovirus Testing in Adolescents

描述（由申请人提供）：Jessica Kahn，医学博士，M.P.H.完成 儿童医院青少年医学和妇科临床培训 他曾在波士顿的一家医院工作，并于年在哈佛公共卫生学院获得公共卫生硕士学位。 1999.然后，她加入了儿童医院医疗中心的教师队伍， 从事以专利为导向的研究。大卫伯恩斯坦，医学博士，该项目 申办者，带来了关于病毒性STI临床研究的专业知识， 广泛的NIH资金，并有指导新研究人员的经验。的 赞助商，顾问委员会成员和合作者组成了一个多学科的 拥有不同专业知识的研究团队。研究环境将支持 教学计划，包括先进的定性和 定量方法，研究伦理培训，以及与其他 临床研究者。卡恩博士的总体职业目标是成为一名 独立的临床研究者，其工作重点是预防 HPV感染与宫颈癌她计划通过 翻译有关1）HPV感染的生物医学方面的数据， 2)对青少年进行HPV检测的心理和行为影响- 预防宫颈癌的具体、有效的临床策略 个人和群体水平。本研究计划的目标是 探讨HPV检测在预防宫颈癌中的潜在作用 针对青少年的项目。实现的具体目标和方法 每一个目标都遵循。 目的1确定青少年巴氏涂片随访的预测因素。要求1 将使用来自490个城市样本的现有前瞻性数据进行检查， 不同种族的青少年 目的2探讨HPV阳性对心理和行为的影响 在女大学生中进行测试。目标2将利用现有的 从608个不同种族的大学女生的样本中收集数据。 目的3探讨大学生的心理、行为和人际关系 HPV阳性和巴氏涂片检查对青少年的影响。目标3、4和5 将使用前瞻性收集的定性和定量方法进行检查 250名HPV感染高危城市少女样本的数据。 目的4确定HPV DNA自我检测的准确性和可接受性 在上述城市青春期女孩的样本中。 目的5确定累积流行率和持续率， HPV感染的消退以及HPV检测结果与宫颈炎的相关性 在上述城市少女样本中，

DESCRIPTION (provided by applicant): Jessica Kahn, M.D., M.P.H., completed clinical training in Adolescent Medicine and Gynecology at Children's Hospital, Boston and an MPH degree at the Harvard School of Public Health in 1999. She then joined the faculty at Children's Hospital Medical Center to pursue a career in patent-oriented research. David Bernstein, MD, the project Sponsor, brings expertise in clinical research regarding viraI STI, has extensive NIH funding, and has experience mentoring new investigators. The Sponsor, Advisory Board Members and Collaborators form a multidisciplinary research team with diverse expertise. The research environment will support a didactic program that includes relevant courses in advanced qualitative and quantitative methods, training in research ethics, and interaction with other clinical investigators. Dr. Kahn's overall career goal is to become an independent clinical investigator whose work will focus on the prevention of HPV infection and cervical cancer. She plans to achieve this goal through the translation of data regarding 1) the biomedical aspects of HPV infection and 2) the psychological and behavioral impact of testing for HPV into adolescent- specific, effective clinical strategies for cervical cancer prevention at the individual and population levels. The objective of this research plan is to explore the potential role of HPV testing in cervical cancer prevention programs targeting adolescents. The specific aims and methods for achieving each aim follow. Aim 1 To determine predictors of Pap smear foIlow-up in adolescents. Aim 1 will be examined using existing prospective data from a sample of 490 urban, racially diverse adolescents. Aim 2 To examine the psychological and behavioral effects of positive HPV testing in female college students. Aim 2 will be examined using existing longitudinaI data from a sample of 608 racially diverse college women. Aim 3 To explore the psychological, behavioral, and relationship-related effects of positive HPV and Pap smear testing in adolescents. Aims 3, 4, and 5 will be examined using prospectively collected, qualitative and quantitative data in a sample of 250 urban adolescent girls at high risk for HPV infection. Aim 4 To determine the accuracy and acceptability of self-testing for HPV DNA in the above sample of urban adolescent girls. Aim 5 To determine the cumulative prevalence and rates of persistence and regression of HPV infection, and correlation of HPV test results with cervicaI cytology, in the above sample of urban adolescent girls.