A NETWORK OF RESEARCH UNITS TO STUDY CLINICAL WOUND CARE

描述(摘自申请者摘要)： 仅次于普通感冒，创伤是人们最常见的原因 在美国寻求医疗服务。估计有39亿美元 仅治疗简单的撕裂伤每年都会产生费用。我们的大多数人 关于伤口治疗的知识和建议是基于旧的 与基础科学研究相关的教条，与临床意义不大。 缺乏临床结果研究来确定最有效的治疗方案 方法创伤性创面的治疗。建议申请的目的是 将候选人培养成独立的职业临床结果研究人员 通过正规的培训和实践经验。该项目的培训目标 候选人将完成临床研究(MCR)硕士学位 加州大学旧金山分校(UCSF)。MCR需要36 1/4小时的授课课程，根据考生的需要和 发表原创科学论文以代替硕士论文。它 与教师导师建立了牢固的导师关系。这个 实践体验的目标将通过完成两个科学 在颁奖过程中的项目。在颁奖过程的早期， 候选人将开发和实施临床研究单位(CRU)在 加州大学旧金山分校的急诊科。通过对筛选实施该方案， 招募和招募患者进行随机试验，以确定最佳治疗方法 治疗单纯性手部撕裂伤将完成。在这项试验中，保守派 管理(非缝合)将与传统缝合进行比较 管理层。主要结果将是三个月的美容和伤口愈合， 疼痛、时间和患者满意度的次要结果也是 评估过了。在获奖的最后几年，当候选人完成他的MCR 并全面发展他的本地CRU，他将成为一个多中心的临床试验 调查员。这将通过使用他的正式训练和 他的导师、加州大学校长卡明斯博士的帮助 加州协调中心(UCCC)。UCCC是专门为帮助 开展多中心临床试验。使用UCCC资源进行试验 将使用使用公共数据库和数据收集技术的网络 对避孕药的使用进行多中心临床试验 治疗狗咬伤的抗生素。在这项研究中 阿莫西林/克拉维酸将与安慰剂进行比较。其主要结果是 这项研究将受到感染。研究的其他结果将是伤口愈合。 患者满意度和成本。

DESCRIPTION (Taken from the applicants abstract): Next to the common cold, traumatic wounds are the most common reasons people seek medical care in the United States. An estimated 3.9 billion dollars of charges are incurred yearly to treat simple lacerations alone. Most of our knowledge and recommendations regarding the treatment of wounds is based on old dogma related to basic science research that has little clinical relevance. There is a lack of clinical outcomes research to determine the most efficient method to treat traumatic wounds. The purpose of the proposed application is to develop the candidate into an independent career clinical-outcomes researcher through formal training and practical experience. The training goal of the candidate will be to complete a Masters of Clinical Research (MCR) at the University of California, San Francisco (UCSF). The MCR requires 36 quarter-hours of didactic courses tailored to the candidates needs and publication of an original scientific paper in lieu of a Masters thesis. It involves strong preceptor relationships with faculty mentors. The practical-experience goal will be achieved by completing two scientific projects during the course of the award. Early in the course of the award, the candidate will develop and implement a clinical research unit (CRU) in emergency medicine at UCSF. Through implementing this program to screen, recruit and enroll patients a randomized trial to determine the best way to treat simple hand lacerations will be completed. In this trial conservative management (non-suture closure) will be compared to traditional suture management. The primary outcome will be three month cosmesis and wound healing, with secondary outcomes of pain, time and patient satisfaction also being assessed. In the later years of the award, as the candidate completes his MCR and fully develops his local CRU, he will become a multi-center clinical-trials investigator. This will be accomplished by using his formal training and with the help of his mentor, Dr Cummings, the Director of the University of Califomia Coordinating Center (UCCC). The UCCC is specifically designed to help run multi center clinical trials. With the use of the UCCC resources a trials network utilizing common databases and data collection techniques will be used to undertake a multi-center clinical trial on the use of prophylactic antibiotics for the management of dog bites. In this study amoxicillin/clavulanic acid will be compared to placebo. The primary outcome of the study will be infection. Other outcomes studied will be wound-healing patient satisfaction and cost.